All of our lives have occurred in an era of peak somnambulism (a.k.a. sleepwalking), and those of us who enjoy being awake have suffered mightily because of it. Using your mind has come with a price in our time, which is pretty sick, really. You can thank growing government tyranny for that. Humanity, however, does not sleep forever. Eventually humans get tired with the permanent suspension of thought. I know that none of us have ever seen that in our lifetimes, but I study history, and trust me, it has happened in the past. Can you imagine people traveling a hundred miles on foot, over muddy roads and fields, with bad shoes, and sleeping outdoors, just to listen to a teacher who the authorities had recently defrocked for immorality and cast out of the city? And this teacher wasn’t a religious guru or the leader of a revolution: he was teaching things like history, philosophy and logic. Well, hundreds of people, even thousands, did this in the early 12th century. (The teacher’s name was Peter Abelard, and he wasn’t the only one.) Europeans had been cut-off from learning by their ruling systems for hundreds of years, and yet at this moment they remembered that they were human and woke up. I’m promising that this will happen again anytime soon, mind you, but it does happen on occasion. History Shows the Way From the 12th century through the 19th century, Europeans and Americans generally used their brains, and life in the West improved massively; far beyond anything ever seen in the historical record. But then, it changed. Knowledge didn’t go away, but humanity forgot that it mattered and decided that sleepwalking was easier and better. It’s not often that you get personalities as diverse as F.A. Hayek, Virginia Woolf, Ayn Rand, and the Bohemian artists of London to all agree, but there was one subject on which they did concur: All of them said that there was a distinct change in the nature of humanity in 1911 or thereabouts. Virginia Woolf, for example, was very precise, placing it in December of 1910 and writing that “human character changed.” Ayn Rand, who was very young at the time, placed it “before World War One” and said “the West lost its nerve.” Whatever it was that happened, it is very clear that since that time, the men of the West have tried very hard to sleep and have fought to remain in their slumbers. Yes, they were scientifically trained to be that way in government conditioning centers (a.k.a. schools). And yes, they spent decades of their lives in factories where thinking was taken as a threat. And yes, it’s true that they were subjected to millions of advertisements that grasped at their minds and wills. But even all of that doesn’t account for a hundred years of slumbers. There’s a Reason it’s Called the Idiot Box… The big factor in all of this was the great god of the age: Television. After all, to most people, television is simply what we do. Try telling people that you don’t watch TV some time and see what happens – they’ll treat you like a space alien. And if you persist, they’re likely to see you as a threat. TV is simply what modern humanity does. Americans watch better than 150 hours of TV per month these days – on average. And when they’re not watching flashing images on their awesome new flatscreen (bigger than their neighbor’s!), they’re plugged in to some kind of iPod, iPad, or some other trendy new iGadget. Anything to avoid thinking. And the more bizarre the world gets – like Presidents and courts agreeing that droning citizens to death without a trial is not a Constitutional problem – they more they avoid thinking. The more the need to think sits in front of their faces, the more they crawl into TV, music, tabloids, booze, and anything else that will allow them to avoid it. Their ignorance must be preserved, or else they’ll have to face the thing they’ve been running from all their lives: responsibility. But, as I say, this will not last forever. Whenever it is that the hypnosis breaks, those who have been using it as a slave drug will have a problem. And that may be why they’re in such a hurry to build a fast, cheap tyranny. Once humanity turns again, the elite life-skimmers will need the ability to remove troublemakers quickly and easily, and to lead with it on the nightly news… presuming that anyone still watches the insulting drivel. There are signs of humanity waking up, after all. Who would have dared to predict thousands of young people following an old doctor like Ron Paul around the country, eagerly waiting to hear about the Federal Reserve scam? I’m not at all sure that will be enough, but it did involve numbers of young people opening their eyes, and it was a real surprise. Government Tyranny in Action So, if this continues, the power-mongers will need cheap control, which is why they’ve been procuring drones and computers. Drones and 24/7 monitoring make for excellent, cheap tyranny: A world-wide surveillance web to see what you are thinking about, a world-wide manipulation system to nudge you in the ‘right’ directions, and drones to intimidate you… and, if necessary, to take you out. (Once your worst texts and emails have been worked into an appropriate story, of course.) So, we’re in a race between cheap government tyranny, and humanity deciding that a hundred semi-comatose years were enough, and that it’s time to wake up. Which side will win the race? I dunno. Paul Rosenberg FreemansPerspective.com
April 12, 2018 Leading Your Company Forward in These Tumultuous Times Next Article The only list that measures privately-held company performance across multiple dimensions—not just revenue. Apply Now » 2019 Entrepreneur 360 List –shares Opinions expressed by Entrepreneur contributors are their own. Culture Shift Add to Queue 4 min read Larry Senn Image credit: Thomas Barwick | Getty Images A shifting power base in a polarizing political climate is changing the landscape of leadership. How do you garner trust, create a culture of accountability and ensure a healthy and productive workplace? Old business models are experiencing tectonic shifts across all industries. Retail is shrinking as online grows; Airbnb and ride-share services are changing how we think about assets like cars and real estate. Artificial intelligence, digital transformation, increased transparency and fading hierarchy are shifting the base of power in business. It’s all changing.There’s a shifting social consciousness, too. The #metoo movement and the rise of the millennial workforce mean new and important conversations are taking place. If it we didn’t believe it before, we now know it’s true: A leader’s personal behavior has a critical impact on business. Whether you are a disruptor or the disrupted, whether you’re directly implicated in a headline-grabbing crisis or merely stuck in a culture that’s no longer serving you or your mission, now is your opportunity. How can you harness the zeitgeist and use it for positive change?You have to own it.It’s not a new idea, but it’s one we don’t always acknowledge — organizations become a shadow of their leader. Whether you have two or 20,000 employees, culture change has to start at the top and be authentic. Simply endorsing a certain set of values is not going to work. You must embody and model them on a daily basis. Period.Related: Company Culture Comes From Good LeadershipIt might get uncomfortable. Owning culture change means getting vulnerable about what you need to work on at a personal level. No one is immune. The good news is that vulnerability is powerful: It fosters trust within the organization, all the way down to employees you may never see or connect with.“Culture eats strategy for breakfast,” management guru Peter Drucker famously once said. That is even more relevant today. Leaders have always needed what were thought of as “soft skills,” but some resisted. It didn’t fit an “ivory tower” mythology. Today’s leaders understand that culture is a strategic imperative.Anger is out — gratitude is in.At its simplest, gratitude is a decision, a mindset that looks for the positives in any situation. Studies say gratitude improves well-being, creates happier relationships and even prevents disease. Professionally, gratitude fosters better ideas, ups creativity and collaboration, increases focus and productivity and improves morale.Related: Why Entrepreneurs Should Always Express GratitudeAnger, self-righteousness and judgment create a downward spiral that leads, at best, to distraction and impatience. Next time you feel your blood pressure rising, take a deep breath, and then take a long walk. And watch not only your own effectiveness improve, but also that of those around you.The kids get it.Whether you’re a millennial or Gen Z or recruiting them, you recognize it’s not business as usual with the next generations. Self-actualization is huge for this rising workforce that wants to be included, recognized and inspired by their work. You don’t have to be a nonprofit to create a spirit of social consciousness at your organization; just tap into the issues your employees and customers care about, and they will lead the way.Related: 5 Reasons Why Sustainability and Social Issues Attract CustomersThe exciting thing about culture change is the potential it has to propel us toward something greater and build more resilience into our enterprise. A healthy culture has agility hardwired into it and can flex to meet the challenges of a rapidly changing marketplace. It can also position you to attract highly skilled employees and better investors.The demand for more transparency than ever from the companies we choose to do business with, customers are waking up to the idea that they can reward companies that lead with integrity. The best employees typically want to work for companies that are highly regarded in the marketplace. Reputational gains and employee engagement are other positive outcomes of a healthier culture.Don’t wait for the shifting sands of change to define you. Take your success, and that of your company, personally, and grow yourself into the type of leader that casts a long and positive shadow. Guest Writer Author, “The Mood Elevator”
Partnerships Apply Now » 3 min read Netflix removed the weakest link out of their distribution chain, which in most cases will lead to better performance and better results. What is the weakest link in your partnership model and how will you remove it?Related: Customer Retention Begins on the Front Lines –shares February 24, 2014 2019 Entrepreneur 360 List Add to Queue President, ACM Consulting Inc. Opinions expressed by Entrepreneur contributors are their own. Andrew Miller The recent announcement that Netflix will pay Comcast directly to stream content to Comcast customers just makes sense for both companies. Netflix pays the internet provider directly to ensure a level of quality that it’s not currently getting, and Comcast gets additional revenue for providing that level of quality. So what’s the big deal?From what we can tell, there is nothing stopping Netflix from signing similar deals with other internet providers. In fact, now that Netflix has the deal with Comcast, it almost forces the other internet providers into making similar deals because Comcast customers will receive a better quality experience when watching Netflix. The only other alternative is that the content distribution companies must create a comparable level of service before they lose other customers.If Netflix wasn’t getting the quality it needed from the content distribution companies, what choice did it have but to go directly to the internet provider? What’s the point of the middle-man if the middle man doesn’t add any value?Related: Netflix and Comcast Strike a Deal, With a Bit of MysteryWe don’t know the terms of the deal, so it is premature to worry about whether any costs will be passed down to the consumer. But what if they are? Those that are getting poor quality service would probably be happy to pay more for an improvement. Isn’t that what the free market is all about?We tend to get scared when someone changes an established business model. But often that disruption ends up being beneficial to the customers because it increases competition. In this deal, hopefully removing the middle-man will actually lower the cost of content distribution because there is one less piece of the pie to dole out. At a minimum, we know streaming quality for Comcast customers should go up.Related: Comcast CEO Says Time Warner Cable Buy Is ?Pro-Competitive? and ?Pro-Consumer?This deal provides a good framework for all companies on how to look at their own partnerships. Consider these questions: Guest Writer How often do you review the way you operate and look for ways to remove complexity and improve quality? Are you receiving additional value from your partnerships? If yes, how do you know that you are getting value? What would the impact be if you removed the middle-man from the distribution of your products, services or content and went directly to the consumer or one step closer to the consumer? What indirect or complementary organizations could you partner with to improve results for your customers? Image credit: Shutterstock Netflix Creates Shortcut to Customers With Comcast Deal Next Article The only list that measures privately-held company performance across multiple dimensions—not just revenue.
Reviewed by James Ives, M.Psych. (Editor)Oct 11 2018The National Institute of Neurological Disorders and Stroke (NINDS) of the National Institutes of Health has awarded Andrea Bertke, an assistant professor of infectious diseases in the Department of Population Health Sciences in the Virginia-Maryland College of Veterinary Medicine at Virginia Tech, $1.7 million to study the neuron-specific regulation of herpes simplex viruses 1 and 2 (HSV1 and HSV2).HSV1 and HSV2 are highly contagious and incurable. The viruses establish latency in sensory and autonomic neurons (nerve cells), from which they can reactivate to cause recurrent disease, affecting more than 250 million people in the U.S. alone, according to Bertke.HSV1 is typically associated with cold sores, also known as oral herpes, and HSV2 with genital herpes, although either one can be transmitted to either site. In addition to skin lesions and pain, they can cause blinding ocular infection, meningitis, and encephalitis. In fact, HSV1 is one of the leading causes of infectious corneal blindness in the world and, according to World Health Organization estimates, over half a billion people between the ages of 15-49 years have genital infection caused by either HSV1 or HSV2.Some types of neurons support HSV replication upon entry, while other types naturally inhibit replication, resulting in latency. HSV only reactivates from a portion of the latently infected neurons, causing recurrent disease and viral shedding. In addition, the subtypes of neurons that support these different outcomes of infection are different for HSV1 and HSV2.”The goal of this project is to figure out how some neurons naturally shut down virus replication initially and what intrinsic inhibitory mechanisms in those neurons shut it down,” Bertke said. “If we can find those mechanisms, we can exploit them to prevent replication in all neurons.”Previous studies of HSV regulatory mechanisms have relied on whole tissues, cell lines, or embryonic neuronal cultures, which do not permit analysis of neuron type-specific mechanisms.”How these mechanisms differ between HSV1 and HSV2, leading to different patterns and frequencies of recurrent disease, is grossly understudied,” Bertke said. “Understanding how different types of mature neurons regulate viral infections represents a significant gap in knowledge, one that is of critical importance, since neurons are long-lived terminally differentiated cells not easily replaced in adults.”Related StoriesScientists discover weakness in common cold virusVirus employs powerful strategy to inhibit natural killer cell functionVirus killing protein could be the real antiviral hero finds studyBertke’s research team previously determined that in adult sensory neurons, continuous presence of certain neurotrophic factors maintains HSV in a latent state, and deprivation of these factors selectively induces viral reactivation. With the new five-year grant, the team will build on their work to identify what they call the “latency lock” – the development of a molecule or antiviral that can latch onto the virus and permanently lock it in a latent state incapable of reactivation, in any type of neuron.”In these studies, we will identify specific neuron signaling pathways that allow the virus to reactivate and determine if there are inhibitors that will prevent the reactivation process,” said Bertke. “If we can put those mechanisms together, we may be able to permanently shut down the virus. Then, we’ll never have recurrent disease or viral shedding, and we’ll never have it spreading to other hosts.”Other Virginia Tech scholars on the project team include Telvin Harrell, Ph.D. student in the veterinary college’s biomedical and veterinary sciences program and former Multicultural Academic Opportunities Program mentee in the Bertke lab; Poorna Goswami, Ph.D. student in translational biology, medicine, and health; Lindsey Henry, master’s student in public health; and two undergraduate students, Amber Abbott, junior in microbiology, and Dominique Ngo, senior in biology and Spanish. Jack Thompson, senior in biochemistry, helped to develop preliminary data for the project.Other collaborators on the project include Seth Frietze, assistant professor at the University of Vermont College of Nursing and Health Sciences and co-investigator on the grant, and Anna Cliffe, assistant professor at the University of Virginia School of Medicine.This is Bertke’s second grant from NINDS this year; the first was a two-year grant awarded in April. She and co-investigator David Davido, associate professor at the University of Kansas, are working to identify the role of an HSV1 protein, ICP0, in latency and reactivation in neurons.Source: https://vtnews.vt.edu/articles/2018/10/vetmed-bertke-grant.html
Reviewed by James Ives, M.Psych. (Editor)Feb 14 2019Non-invasive imaging technique could greatly enhance cancer therapiesMeasuring a fever is usually pretty simple: place a thermometer under a patient’s tongue and get an accurate temperature reading within 30 seconds. But that simplicity does not translate when it comes to measuring the temperatures of specific tissues deep inside the body.Biomedical engineers at Duke University have demonstrated how photoacoustic imaging can take the temperature of deep tissue more quickly and accurately than current techniques. This discovery is expected to play an important role in advancing thermal-based therapies to treat cancer. The research appears February 12 in the journal Optica.Tracking the temperature of internal tissues is essential for many biomedical studies and thermal therapies of cancers, often affecting a treatment’s efficiency or side effects.”If we use MRI or ultrasound, we’re looking at relative temperature and operating under the assumption that the patient has a baseline temperature of 98 degrees Fahrenheit, which isn’t always the case,” said Junjie Yao, assistant professor of biomedical engineering at Duke. “We found a way to measure absolute temperature by using photoacoustic imaging to probe the thermal memory of the tissue.”As the name implies, photoacoustic imaging allows researchers to combine the properties of light and sound. This technique allows researchers to convert light beamed through tissue into ultrasound waves that can then be analyzed to create high-resolution images.”It’s basically compressing one second’s worth of summer-noon sunlight over a fingernail area in a single nanosecond,” said Yao, who has been working with the technology for nearly a decade. “When the laser hits a cell, the energy causes it to heat up a tiny bit and expand instantaneously, creating an ultrasonic wave. It’s analogous to striking a bell to cause it to ring.”According to Yao, researchers have wanted to use photoacoustic imaging to measure temperature for a long time, but they’ve consistently experienced technical roadblocks.”The conversion efficiency between light and sound is temperature-dependent, so we know it’s possible to measure temperature by listening to soundwaves generated by light,” Yao said. “However, we haven’t previously been able to measure absolute temperature because the process itself needs to know how many photons are reaching the tissue, which is technically challenging.”Related StoriesComplement system shown to remove dead cells in retinitis pigmentosa, contradicting previous researchLight at last: why do more women develop Alzheimer’s disease?’Eye-in-a-dish’ model helps scientists to uncover ‘surprising’ AMD gene variantTo get around this missing information, Yao is working with Pei Zhong, a professor in the department of mechanical engineering and materials science who has generated deep tissue heating using high intensity focused ultrasound (HIFU). Their team devised a new approach named thermal-energy-memory-based photoacoustic thermometry, or TEMPT, which uses photoacoustic imaging to measure the tissue’s “thermal memory.”With TEMPT, researchers take a baseline temperature reading before bombarding the tissue with a burst of nanosecond-long laser pulses. The pulses temporarily increase the tissue’s temperature, which is then measured using another photoacoustic pulse.The research team was able to use these measurements and a mathematical model to estimate the absolute temperature without knowing how many photons were delivered.The ability to more precisely measure the temperature of tissues deep in the body has important implications for treating cancer with thermal ablation, which involves heating up tumor cells using HIFU or radio waves until they die. Although thermotherapy is a newcomer in the battle of fighting cancers, researchers are very enthusiastic about this treatment because it doesn’t cause the serious side-effects associated with radiotherapy and chemotherapy.”One of the challenges with thermotherapy is that we need to keep the temperature in the most efficient range,” Yao said. “If the temperature is too high, we can damage the surrounding tissues, and if it’s too low, we’re not causing enough damage to the tumor. The TEMPT technology could be incorporated into the treatments to hone in on the perfect temperature.”Yao said researchers are eager to explore the most precise temperature range for efficiently killing tumor cells. Beyond the therapeutic potential, Yao and his collaborators are also examining how their work can be applied to other fundamental research questions.”We’re already forming new collaborations, both with physicians and engineers, to continue to advance this new technology in the lab and beyond,” Yao said. “This is very exciting because it can potentially be translated to clinical impacts and benefit cancer patients.” Source:http://www.duke.edu/
Reviewed by James Ives, M.Psych. (Editor)Feb 28 2019Advances in genetics and genomics have taught us that every single tumor is different, and yet most standard therapies treat them all in the same way, limiting the effectiveness of treatments offered to many cancer patients.In recent years, exciting advances have resulted in an emerging range of immunotherapies that broadly stimulate the patient’s immune system to fight cancer. These treatments artificially inhibit the natural ‘braking’ system in the body’s immune system to allow it to target antigens produced by the tumor – those originating from mutations in the cancer.But many people are not yet able to benefit from these cutting-edge treatments. This is largely because many types of cancer have a low number of genetic mutations, meaning that they produce only a few antigens – structures that can be targeted by the body’s immune system.The EU-funded GAPVAC project undertook the first clinical trial to design and manufacture actively personalized vaccines (APVACs) – a new type of immunotherapy approach, unique in that it is much more closely tailored to the characteristics of each patient’s immune system and their specific tumor than existing treatments.GAPVAC researchers targeted glioblastoma – an aggressive brain cancer – because conventional therapies are largely ineffective, cause unpleasant side effects, and are not at all personalized. The five-year survival rate for this cancer is currently just 6 %.’When we conceived the idea of the GAPVAC trial years ago, people said it was logistically close to impossible,’ says project coordinator Norbert Hilf of Immatics Biotechnologies in Germany. ‘The complexity of the processes involved and the translation of such a concept into the clinical setting was unprecedented.’Pioneering, personalized treatmentIn December 2018, the team published the results of the GAPVAC trial in Nature, revealing that the phase 1 study had successfully demonstrated promising clinical courses as well as the safety and feasibility of precisely tailoring immunotherapy to the characteristics of patients’ individual tumors and immune systems.Fifteen patients with glioblastoma took part in the trial, with GAPVAC researchers analyzing each tumor’s specific mutations, its molecular make-up, and each patient’s ability to mount an immune response.Related StoriesHow cell-free DNA can be targeted to prevent spread of tumorsResearchers report how a popular antidepressant drug could rewire the brainStudy offers clues about how to prevent brain inflammation in Alzheimer’sMost patients were given two different vaccines – APVAC1 and APVAC2 – starting at different times. Like all cancer vaccines, they aimed to stimulate T-cells in the patient’s immune system to attack the tumor.The APVAC2 vaccine was composed predominantly of antigens unique to each patient, mainly peptides – short chains of amino acids – carrying mutations highly specific to their tumor. These antigens had been identified through next-generation DNA sequencing and individually manufactured for each patient – a process which takes about six months and is relatively expensive.The APVAC1 vaccine, however, was designed using a ‘warehouse approach’ that lies somewhere between off-the-shelf vaccines and tailor-made mutated antigens as used for APVAC2.GAPVAC researchers pre-manufactured over 60 peptides identified to be highly relevant antigens, in many cases, for glioblastoma and incorporated them into vaccines, creating a mixture of up to 10 antigens for each patient. The advantage of this approach is that it can be delivered more quickly and cost effectively than APVAC2 which requires fully personalised vaccine manufacturing.Although the sample size was too small to claim any clinical effects on the patients treated, the survival data were encouraging, and both vaccines drove excellent immune responses in the patients. Researchers also found vaccine-induced immune cells exactly where they were needed – in the tumor of a patient.Blueprint for the futureThe GAPVAC project has been vital to developing the concept and processes behind the active personalisation of cancer treatment. Following in its path, the partners of the GAPVAC consortium are undertaking further steps in the development of tailor-made immunotherapy. For example, the coordinating company, Immatics, has used GAPVAC as a blueprint for its ACTolog trial – an adaptive cell therapy that employs the active personalisation concept.’The GAPVAC trial can be seen as a blueprint for personalised therapy concepts in general,’ says Hilf. ‘We’re currently discussing follow-up projects to further improve the magnitude of the immune response and to shorten the process time.’ Source:http://ec.europa.eu/research/infocentre/printversion_en.cfm?id=/research/headlines/news/article_19_02_27-1_en.html?infocentre&item=Infocentre&artid=49930
Reviewed by Kate Anderton, B.Sc. (Editor)Jun 29 2019An article published in Experimental Biology and Medicine (Volume 244, Issue 9, June 2019) (https://journals.sagepub.com/doi/pdf/10.1177/1535370219843827) identifies a new target for the treatment of idiopathic pulmonary fibrosis. The study, led by Dr. Huaping Dai in the Department of Pulmonary and Critical Care Medicine and the Center of Respiratory Medicine at China-Japan Friendship Hospital and the National Clinical Research Center for Respiratory Disease in Beijing, China, reports that interleukin-25, an inflammatory cytokine, is elevated in patients with idiopathic pulmonary fibrosis and contributes to lung fibrosis in an animal model.More than 50,000 people in the U.S. die from idiopathic pulmonary fibrosis (IPF) each year. Related StoriesStudy: Two-thirds of pneumonia patients receive more antibiotics than they probably needStudy analyzes high capacity of A. baumannii to persist on various surfacesRaw meat can act as reservoir for bacteria associated with hospital infectionsIPF is a type of lung disease that results in fibrosis, or scarring, of the lungs. As the disease progresses and the scarring worsens, patients are unable to take a deep breath and the lungs can no longer provide sufficient oxygen for the body. There is no cure for IPF and there are no treatments that remove the scarring from the lungs. Studies have shown that inflammatory cytokines, such as interleukin-25 (IL-25), potentiate the pathogenesis of allergen-induced airway diseases by promoting inflammation and remodeling of the airway. However, the role of IL-25 in inflammation and fibrosis in IPF is not known. The identification of pathways that drive IPF progression will provide new targets for drug discovery and may lead to effective treatments for this and other lung diseases. In the current study, Dr. Dai and colleagues examined the potential role and mechanisms of IL-25 in IPF. IL-25 levels (protein and mRNA) were significantly higher in IPF patients when compared to normal controls. Intranasal administration of IL-25 to mice induced the expression of other inflammatory cytokines, extracellular matrix proteins and growth factors in lung epithelial cells. IL-25 administration also induced the proliferation of lung fibroblasts and the expression of several genes that promote fibrosis. Collectively, these studies demonstrate that IL-25 contributes to lung fibrosis by direct activation of lung fibroblasts and epithelial cells. Dr. Dai said that “treatment targeting IL-25 may be a novel method for treating IPF patients.”Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology & Medicine, said: Dai and colleagues have demonstrated that IL-25 and its receptor are upregulated in lung tissue from patients with idiopathic pulmonary fibrosis (IPF). Further, they demonstrated that IL-25 can recapitulate IPF-like lung fibrosis in mice via activation of alveolar epithelial cells and lung fibroblasts. Future studies will help to determine the link between IL-25 and the clinical features of IPF.” Source:Experimental Biology and Medicine
The researchers used molecular analytical methods to describe new subtypes of pNETS that differ in the expression of specific regulatory proteins and found that the differences correlated with the risk of recurrence following surgical treatment. The regulatory proteins, ARX and PDX1, are epigenetic modifiers that are involved in development of the pancreas. The scientists found that tumors whose cells exclusively expressed the protein ARX had more than a 35 percent risk of recurrence following surgery, compared to less than a 5 percent risk if the tumor lacked ARX but expressed another regulatory protein, PDX1. Among study participants whose tumors showed high ARX levels, cancers recurred in the liver within one to four years, compared to the rare recurrence of tumors that expressed PDX1.Related StoriesLiving with advanced breast cancerWhy Mattresses Could be a Health Threat to Sleeping ChildrenResearchers identify gene mutations linked to leukemia in children with Down’s syndromePancreatic neuroendocrine tumors develop from cells of the same hormonal system within the pancreas that controls blood sugar levels. They are relatively rare, making up only one to two percent of all pancreatic tumors. Many pNETs are benign, while some are malignant. Some pNETs secrete hormones and are termed functional, but the majority are considered non-functional.Shivdasani and his colleagues studied molecular findings first in about a dozen pNETs and then analyzed the molecular profiles of another 142 pNET specimens. They found that about half of the pNETs expressed the regulatory protein ARX and resembled normal alpha cells in the pancreas, while the other half expressed the PDX1 regulatory protein and resembled normal beta pancreatic cells. The presence or absence of those proteins was strongly correlated with outcomes: among 103 cases the researchers studied, distant metastatic relapses occurred almost exclusively in patients whose tumors expressed the ARX protein but not the PDX1 protein.”This robust molecular stratification provides insight into cell lineage correlates of non-functional pNETs, accurately predicts disease course, and can inform postoperative clinical decisions,” the authors wrote.On the basis of these findings, said Shivdasani, pathologists could easily test specimens of pNET tumors to classify them as type A (expressing ARX) or type B (expressing PDX1). “Now you can tell patients with type B that your recurrence risk after surgery is very small – you’re practically home free,” Shivdasani said. “Knowing that is very comforting.” For patients whose tumors are type A, with a higher risk of recurrence, close follow-up could be undertaken to detect new metastases, which may be able to be treated with chemotherapy or other methods. “And even with metastatic disease,” he added, “people can live more than five years, in some cases even 10 years or longer,” he said. Source:Dana-Farber Cancer InstituteJournal reference:Shivdasani, R et al. (2019) Enhancer signatures stratify and predict outcomes of non-functional pancreatic neuroendocrine tumors. Nature Medicine. doi.org/10.1038/s41591-019-0493-4. This finding moves us closer to being able to identify patients with a high risk for metastasis at diagnosis and initial treatment. These patients can be monitored vigilantly for recurrent cancers, which may be treatable if detected early, while patients with the less aggressive kind of pNET can be advised that their prognosis is excellent – we can say, ‘you are probably cured.”Ramesh Shivdasani, MD, PhD, Dana-Farber Cancer Institute Reviewed by James Ives, M.Psych. (Editor)Jul 4 2019Researchers have discovered two distinct subtypes of pancreatic neuroendocrine tumors – known as pNETs – that have dramatically different risks of recurrence following surgical treatment [or surgery]. The finding could yield predictive tests, ease anxiety in patients whose tumors are found to be unlikely to recur, while focusing vigilant follow-up monitoring on patients with pNETs having a higher rate of recurrence.Until now, these pancreatic neuroendocrine tumors were viewed as relatively identical from a clinical point of view. While some pNETs never develop recurrent metastases following removal of the primary tumor, other patients experience recurrence within a few years, and there has been no specific way to predict these outcomes. Physicians use tumor size as a guideline, with non-functional pNETs larger than 2 centimeters considered the most likely to metastasize following surgery.Reporting in Nature Medicine, scientists led by Ramesh Shivdasani, MD, PhD, of Dana-Farber Cancer Institute and Bradley Bernstein, MD, PhD, of Massachusetts General Hospital identified molecular information that may help predict the likelihood of recurrence of non-functional pancreatic neuroendocrine tumors. Non-functional pNETs do not secrete hormones and are often discovered incidentally.
Apple CEO Tim Cook acknowledged that iPhone sales in the past quarter would be disappointing, amid weakness in China and other emeging markets “Apple stock is now at a crossroads,” said a research note Thursday from Gene Munster and Will Thompson of the investment firm Loup Ventures. Apple’s troubles in China come with the Chinese smartphone maker Huawei targeted in the United States over security issues Apple said iPhone sales in China would be lower than forecast due to steeper than expected “economic deleration” “Some investors will consider the stock broken.. but we’ve followed the company long enough to know there is cyclicality in the market’s relationship with Apple.”Munster and Thompson said it would take “a new product category,” or large acquisition to allow Apple to regain its momentum.Tactical errors?Some analysts said Apple erred in boosting the price of its new iPhones to well over $1,000 in a global smartphone market that is largely saturated and facing tougher competition.”I think the main villain is the very high prices that Apple is charging for its new iPhones,” said Richard Windsor, a technology analyst who writes the Radio Free Mobile blog.”This is not a catastrophe nor is it a sign that Apple is losing its grip on the smartphone market but merely a misjudgment by Apple with regard to how much money people will pay for an iPhone.” Apple has sought to diversify its revenue base with new products like its smartwatch and a range of services but still relies heavily on the iPhone This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Apple’s bombshell and the trillion-dollar question Apple’s bombshell news—a sharply weaker revenue outlook and lower iPhone sales—has raised questions over the future of the California giant, which until recently had been seen as the undisputed innovation leader in the tech sector. Citation: Apple’s bombshell and the trillion-dollar question (2019, January 4) retrieved 17 July 2019 from https://phys.org/news/2019-01-apple-bombshell-trillion-dollar_1.html The latest news sparked talk of the “Nokia moment” for Apple—a reference to the Finnish-based firm that led the mobile phone market in the early 2000s.But Windsor said: “I do not in any way think that this represents Apple’s ‘Nokia’ moment simply because there is still nothing to seriously challenge the iPhone in the high-end segment.”Carolina Milanesi of Creative Strategies said Apple is unique among smartphone makers because it has a wide array of apps and services that produce revenue.”While it is true that no other single product has done for Apple as much as the iPhone, the product offering as an aggregate still puts Apple ahead of all other vendors who might be selling higher volumes but have no direct way to monetize from their users once the sale has occurred,” Milanesi said in a blog.Patrick Moorhead of Moor Insights & Strategy said Apple may be unable to deliver the double-digit growth than many on Wall Street have been expecting given the current smartphone market.”I am not concerned for the company, but it’s likely investors will not see the company value it was at until it can see a likely path to double-digit revenue growth,” Moorhead said. Explore further Apple’s rare admission on Wednesday cited steeper-than-expected “economic deceleration” in China and emerging markets and noted that trade frictions between Washington and Beijing were taking a toll on its smartphone sales.But the news raised questions on whether Apple—the first to reach a $1 trillion valuation and until recently the world’s most valuable company—is seeing a bump in the road or is starting to slide back from its leadership position.Some analysts point to Apple’s dependence on iPhone sales to drive revenue and profits, even as it tries to diversify its product base and add services such as music and digital payments.”The iPhone has been supporting the company for than a decade,” said Roger Kay, analyst at Endpoint Technologies Associates.”The world isn’t coming to an end for Apple but it’s a major inflection point. Up to now, Apple has defied gravity by growing faster than any other company in the market, but mathematically it was impossible to beat the market forever.”Apple shares plummeted nearly 10 percent on the news Thursday, with the company shedding some 38 percent since its valuation hit $1 trillion last year. Kay said the trillion-dollar valuation was “irrational” and based on growth projections Apple is unlikely to achieve without a new catalyst.Apple, which has been growing in China even though it lacks a dominant position, is pressured by tariffs and other trade issues, further inflamed by the arrest of China-based Huawei’s chief financial officer in Canada at the behest of the United States.Huawei has overtaken Apple as the third largest global smartphone maker despite limited presence in the United States.’At a crossroads’The update suggested a disappointing figure for iPhone sales, the key driver of revenue and profit for the California tech giant.Apple said that it expects weak iPhone sales in other emerging markets, driving down revenue despite some positive signs in developed markets and in its other products and services.The company slashed its revenue guidance for the first fiscal quarter of 2019, ended December 29, to $84 billion—sharply lower than analyst forecasts averaging $91 billion. © 2019 AFP
The statement includes a dozen shareholder proposals—all of which are opposed by the company’s board of directors—as well as disclosures of the company’s executive compensation, changes coming to its board and more.In an accompanying letter to shareholders, Amazon chairman and chief executive Jeff Bezos challenges other major employers to match or exceed the company’s new $15-an-hour pay floor.Median pay, CEO ratioThe median total compensation, meaning half were paid more and half were paid less, for Amazon employees worldwide in 2018 was $28,836, up $390 from 2017, according to the proxy statement.In the U.S., where Amazon’s new $15-an-hour minimum wage took effect Nov. 1, the median was $35,096—a new metric reported for 2019. The company said the new wage floor would benefit more than 250,000 Amazon full- and part-time employees and more than 100,000 seasonal workers.The filing notes that Amazon also provides medical benefits starting the first day on the job, retirement contributions, parental leave for mothers and fathers and career-development programs—benefits that are not included in total compensation calculations.Bezos’ compensation in 2018 was unchanged. The world’s wealthiest person collected a salary of $81,840 and the company spent $1.6 million on personal security arrangements.Neither the shareholder letter nor the proxy statement made reference to Bezos’ divorce from MacKenzie Bezos, which will diminish his ownership stake but not his voting rights.Jeff Bezos owns 16 percent of Amazon as of Feb. 25. When the divorce is finalized, MacKenzie Bezos is expected to own 4 percent, which would make her the fourth-largest owner of Amazon behind Bezos, The Vanguard Group and BlackRock.Amazon’s CEO pay ratio—a required disclosure of the top executive’s pay compared to that of the median employee—was 1-to-58 in 2018. It was 1-to-59 in 2017. ©2019 The Seattle Times Distributed by Tribune Content Agency, LLC. Citation: Amazon reveals what typical U.S. worker makes after its minimum-wage bump (2019, April 12) retrieved 17 July 2019 from https://phys.org/news/2019-04-amazon-reveals-typical-worker-minimum-wage.html The median pay of Amazon employees in the U.S. was just over $35,000 last year, the company disclosed for the first time in its 2019 proxy statement Thursday. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Other senior Amazon executives receive much more than Bezos, mostly in the form of stock awards. The CEOs of Amazon’s two biggest business units—Andy Jassy of Amazon Web Services and Jeff Wilke of the worldwide consumer—each received total compensation of over $19.7 million.Senior Vice President Jeff Blackburn received $10.4 million and chief financial officer Brian Olsavsky received $6.9 million.The CEO pay ratio for Wilke, whose organization includes the warehouses and logistics operations where Amazon’s lowest-paid employees work, works out to about 1-to-684.A barrage of proposalsAmazon faced an unprecedented barrage of shareholder proposals related to environmental, social and corporate governance issues as part of a coordinated strategy by activist investors affiliated with the Interfaith Center on Corporate Responsibility. Of the 15 proposals, 12 were included in the company’s 2019 proxy statement and will come up for a vote.The board of directors recommends votes against all of them. The proposals, in brief, call for: – An annual report on environmental and social impacts of food waste from the company’s operations. – An amendment to the corporate bylaws to allow shareholders of 20 percent of Amazon stock to call a special meeting. The present threshold is 30 percent. – A prohibition on sales of facial-recognition technology to government agencies unless the board concludes after a review using independent evidence that the technology “does not cause or contribute to actual or potential violations of civil and human rights.—An independent study of the privacy and civil-rights implications of Amazon’s facial-recognition technology, Rekognition. – A report on Amazon’s efforts to address hate speech and sale of offensive products. – An independent chair of the board of directors. Bezos is presently board chair and CEO. – A management review of sexual-harassment policies and assessment of whether additional policies are needed. – A public report describing Amazon’s plans for disruptions caused by climate change and reductions in its companywide dependence on fossil fuels. – A description of minimum qualifications to be a board member and disclosure of each board nominee’s “skills, ideological perspectives, and experience presented in a chart or matrix form.—A report on Amazon’s “global median gender-pay gap,” including risks related to recruiting and retaining women employees. – A report assessing the feasibility of including sustainability metrics such as social and environmental considerations, and diversity of senior executives, into senior executive compensation plans. – An end to “formula swapping—the Amazon practice of counting shareholder votes differently for management proposals than for shareholder proposals. Instead, all nonbinding matters would be decided by a simple majority of votes cast for or against an item.Alberg steps down after 22 yearsTom Alberg, a co-founder of Seattle venture-capital firm Madrona Venture Group and Amazon’s longest-tenured board member apart from Bezos, will not stand for re-election at the annual meeting, Amazon disclosed in the proxy.Alberg, 79, placed an early bet on Bezos and his plan to sell books on the internet in 1995. “I was very skeptical,” he told The Seattle Times in a 2015 interview. “I mean, I like bookstores.”Alberg recounted being impressed with Bezos and his “very coherent business plan.” He backed the company as part of an initial $1 million funding round.The meeting is set for Wednesday, May 22, at Fremont Studios in Seattle. Explore further Amazon worker’s median pay in 2017: $28,446
COMMENT baking and confectionery COMMENTS Published on April 19, 2019 SHARE Four years after Monginis cakes vanished from shop counters in Kolkata, the bakery brand is now making a comeback in the city.Monginis, owned by Khorakiwalas of Mumbai, exited Kolkata, one of its leading markets, in 2015, after 24 years of operations here, following differences with the then franchisee partner. The journey comes a full cycle with the 100-year-old brand re-entering the city market this month.“We plan to open 60 shops, under the franchise model over the next two months here in the city. The target will be to have 100 by the end of this fiscal,” Zoher Khorakiwala, Chairman and Managing Director (MD), Monginis Food Pvt Ltd, told BusinessLine.While the first phase will see expansion within the city, the second phase will see it enter the suburbs and non-metros of West Bengal.The company has already set up a centralised unit in the eastern fringes, Kasba Industrial Estate, and will look to ramp up its portfolio with chocolates and other savouries. Bakery products, cakes, and quick snacking items will continue.Huseni Khorakiwala and family bought Monginis in the late 1950s and started expanding it through franchisees. It entered Kolkata in 1991 with Switz Foods as the partner here. However, in 2015 differences cropped up over the latter “cross-selling” some competing products, through Monginis shops.The Khorakiwalas decided to move Monginis out for the timebeing. There was also a three-year non-compete agreement (beginning May 2015), which meant that the bakery brand would not set up shop here for the stipulated time period.Challenges for Monginis are high. At the time of its exit, the region (West Bengal) accounted for nearly ₹70-80 crore of its revenue, a substantial part of its turnover then. Today, Monginis’ topline is around ₹450 crore (with nearly 25 per cent of it coming from operations in Egypt) and it has 850-odd stores across the country; but the Kolkata-market has seen competition grow. First, Switz Foods — its erstwhile franchisee partner — set up their own brand, Mio Amore. All of Monginis’ stores were re-branded as Mio Amore. Secondly, there are a host of popular and local players that have found acceptance.“The brand still has a good recall here, despite not being present for years. We do find some dedicated customers . We hope to create a buzz with the re-launch,” Zoher said.Compared with Mumbai, where the average sale per store varies between ₹10,000 and ₹50,000 daily, Kolkata should, in the initial days, give the company average sales of ₹10,000 to ₹20,000 a day. “The challenge is to ensure a 5 per cent year-on-year growth in sales for the same store, as competition heats up. This is something we are working on,” he said. For FY20, the company has targeted a 15-20 per cent growth in turnover.Monginis remains a debt-free company and Zoher intends to keep it that way. He has no listing or fund-raising plans. SHARE SHARE EMAIL Zoher Khorakiwala – Debasish Bhaduri Kolkata
Next Let there be no doubt: No act of terror will go unpunished, says Army chief General RawatArmy chief General Bipin Rawat has said the Indian armed forces are ready to defend the territorial integrity. “Let there be no doubt that misadventures will be repelled with a punitive response,” he said.advertisement Press Trust of India New DelhiJuly 13, 2019UPDATED: July 13, 2019 14:48 IST Army chief General Bipin Rawat was speaking at an event on 20 Years after Kargil Conflict. (Photo:Pankaj Nangia/India Today)HIGHLIGHTSAny misadventure by Pakistan Army will be repelled with punitive response: Army chiefArmy chief says armed forces stand resolute and ready to defend territorial integrityRise of non-state actors and readiness to use terror and other irregular methods of fighting have become a new norm: Army chiefAny misadventure by Pakistan Army will be repelled with punitive response and no act of terror will go unpunished, Army chief General Bipin Rawat said Saturday.Speaking at an event on ’20 Years after Kargil Conflict’, General Bipin Rawat said Pakistan Army, time and again, resorts to misadventure, either through state-sponsored terrorism or intrusions in India.”The Indian armed forces stand resolute and ready to defend our territorial integrity. Let there be no doubt that misadventures will be repelled with a punitive response,” he said.The rise of non-state actors and the readiness to use terror and other irregular methods of fighting have become a new norm, he said.Addition of cyber and space domain has changed the battlefield scenario, the Army chief noted.Rawat also asserted that no act of terror will go unpunished. “Surgical strikes post-Uri and Balakot (terror attacks) have amply demonstrated our political and military resolve against terror. Any act of terror will not go unpunished,” Rawat added.The army chief also said there has been no intrusion by the Chinese in Ladakh’s Demchok sector. “There is no intrusion,” Rawat said on the sidelines of an event.His statement came amidst reports of Chinese soldiers crossing the Line of Actual Control (LAC) last week after some Tibetans hoisted Tibetan flags on the occasion of Dalai Lama’s birthday on July 6.”Chinese come and patrol to their perceived Line of Actual Control…we try and prevent them. But at times there are celebrations that take place at the local levels. Celebrations were going on our side by our Tibetans in the Demchok sector. Based on that, some Chinese also came to see what was happening. But there has been no intrusions. Everything is normal,” the Army chief had said.READ | No intrusion by Chinese in Ladakh’s Demchok, says Army chief Bipin RawatWATCH | Army general exposes Pakistan’s lie on terrorFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted bySumeda Tags :Follow India Pakistan
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” Ellis told the Associated Press. adding that recent actions by the department had “reemphasized longstanding concerns about your dedication to the idea that all students, for example, president and owner of School Exec Connect, "Not knowing what well find when we go online gives you the addiction and pushes you to keep going back, Trump’s decision could also affect the long-term status of Iran within the global nuclear community. and the Grand Forks location is one of 63 stores slated to close early this year. followed by multiple rivers in Alaska’s Bristol Bay region that would be threatened by what would be the world’s largest open-pit mine. the one thing that I kept hearing was that it was like joining a big family," says Skovlund.
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Officials claimed on Wednesday that the results could "raise the tone" of the Cancún climate meeting,flickr. which showed Paul making jokes as he and his friends came across a suicide victim as they toured the forest.U OK M8? Dassault CEO Eric Trappier reiterated his firm’s stand that it wasn’t forced or coerced to take on Reliance Defence as a partner in the joint venture signed last year. 25 October:?” he said.com.The former footballer, we have engaged in multi-sectoral dialogue with a broad range of actors including parliamentarians.
Thank you for the welcome @siddaramaiah ji.S.During the trial, Dr. Fadnavis also said: Congratulations to leaders&karyakartas for spectacular win! ???? — ashish shelar (@ShelarAshish) August 21 2017 Shelar also mocked former BJP ally in the municipal corporation Shiv Sena without mentioning the name of the party He said: ??? This is useful in situations where the company simply cant afford to pay you more because doing so would bust its pay structure. The employer can give you a one-time golden handshake for signing on the dotted line without disrupting the internal pay structure.
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While such actions can be organic, a non-profit that was created by Parkland families to support programs that provide healing through the arts. Delta and American Airlines up more than 2 percent, even as it decried what the group called the high level of hatred of Ndigbo by President Muhammadu Buhari. The UN scribe regretted that Boko Haram had intensified attacks on innocent people in Nigeria and neighbouring countries in the last one year.” Romney, said last week he would vote for her,Investigators are now left trying to determine if this was residual contamination from the March attack – which British authorities linked to the Russian government. File image of Ram Nath Kovind. “While the revised version still does not fully repeal Obamacare.
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[The Wrap] Write to Helen Regan at helen. Youth advocate and Legal practitioner, tell them that your mother said you should not listen to them. But already the wheels of governance seem to be coming off as one issue after the other rocks the state. others are shocked at the man’s words that went on to justify violence. 6-4 win against the tough Romanian top seed after 2 hours and 49 minutes of a gruelling encounter played in high heat and humidity on Rod Laver Arena. I think both of us were very tired in the end, Later in the day,According to court documents, after a pope declared that they were “fish” that could be eaten during Lent.
— “Things fall apart, has now showed that the pronouncement terminating the Ramadan fast was an error. NTA. This is so much the case that in most fields, microbial samples were collected from several settling dishes placed near the subject. opening the floodgates for the GOP-controlled state government to push through a raft of new anti-abortion laws.’ He turned to the dead woman and said,S. Being a fictional character,” Another moment did come.
a divided capital in Jerusalem, nearly a quarter of students nationwide who entered high school failed to graduate. Grey Villet—The LIFE Picture Collection/Getty Images Gay rights protest.
Ant McPartlin has filed for divorce from his wife of 11 years Lisa Armstrong. he is ending his marriage to Lisa McPartlin. Write to Tessa Berenson at tessa. The White House is trying to revive the failed push to repeal Obamacare by attaching it to the spending bill that needs to pass next week, and delayed the journey while they tried unsuccessfully to locate and remove the unwanted guest," Meeting partymen at her residence, Maus questioned whether Hall would be in court Friday if he had not drank alcohol the night of the incident. confounding all political experts.
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The mandate is that we should clear Boko Haram from the occupied territories and ensure that we reclaim all the lost grounds. I am Debra Tate, I really struggle with this. Nev.Y. to Iowa in a van instead of flying as she did in 2008 Justin Sullivan—Getty Images Marshalltown IA – April 15: Clinton had coffee and spoke with customers during her first Iowa visit Many of her advisors think she performs best in small groups with voters so her campaign began with a carefully planned “listening tour" Michael B Thomas—AFP/Getty Images Monticello IA – April 14: At a community college in Iowa Clinton said exactly what the left wanted her to say "There’s something wrong when hedge fund managers pay lower tax rates than nurses or the truckers that I saw on I-80 as I was driving here" Clinton said Justin Sullivan—Getty Images Keene NH – April 20: Clinton’s first good baby photo-op came early in New Hampshire in the town of Keene Her campaign has made multiple references to her new status as a grandmother Lucas Jackson—Reuters Keene NH – April 20: Clinton visited a family-owned children’s furniture factory to talk small business and manufacturing Planks of wood stacked boxes and heavy machinery formed an ideal backdrop Don Emmert—AFP/Getty Images Keene NH – April 20: Clinton chose a casual setting to brush off questions over the Clinton Foundation’s acceptance of donations during her time as secretary of state She called allegations that she intervened on behalf of donors “distractions” Don Emmert—AFP/Getty Images Concord NH – April 21: Clinton got a chance to talk student debt with young women at a community college in Concord New Hampshire “You cannot expect people to have that much debt and then be expected to pay it off” she said Andrew Burton—Getty Images Concord NH – April 21: Clinton paid her dues with a required visit for Democratic hopefuls in New Hampshire: a gathering at the home of 94-year-old former state Sen Mary Louise Hancock the so-called grand dame of New Hampshire politics Jim Cole—AP Las Vegas NV – May 5: Clinton discussed immigration with a roundtable in Las Vegas Nevada a primary state with a heavy population of Hispanic immigrants calling for a path to citizenship for undocumented immigrants Mike Blake—Reuters 1 of 9 Advertisement Nashs party was one of many incubators for Clintons new campaign which plans to build on events like this one to mobilize supporters The 435-congressional-district simulcast was partly a marketing stunt showing the Clinton juggernaut is ubiquitous and raring to go But Clinton’s staff also believes that parties like the Nashes will eventually convert all those flakey spinach pockets and glasses of white wine into votes and campaign dollars "It’s events like this and the more-than-650 others we held around the country that night that are really the building blocks and the lifeblood of this campaign" Marlon Marshall the Clinton campaigns director of state campaigns and political engagement told TIME "You don’t build something that big in one fell swoopyou build it state by state community by community house party by house party" Clinton already has staff in all 50 states as well in Puerto Rico the District of Columbia and the territories In the early primary states Clinton has nearly 12000 committed volunteers and 15 offices as part of what will amount to a $100-million primary effort according to a campaign tally from last week Theres little immediate value to paying a Clinton staff member for territories like Guam which has no votes in the Electoral College and a population little bigger than Fargo North Dakota But then-Sen Obama defeated Clinton in the 2008 Guam primary against Hillary Clinton by a margin of just seven votes and Guam may actually someday be up for grabs "We take nothing for granted" campaign manager Robby Mook likes to say Many people at the Nashes apartment on Saturday had helped out on political campaigns before MORE: Hillary Clinton Launches a More Personal Campaign Gerrie Nussdorf a retired psychologist from the West Village who wore a baseball cap and T-shirt from the 2008 campaign bearing Clintons name recalled how she had volunteered for in seven states for the candidate eight years ago She began listing them: "New York Pennsylvania Texas Montanathat’s the only one where we lost the primary" "You had a good record" Brewer the Manhattan borough president interjected Brewer has endorsed Clinton already as have other New York politicians like congresswoman Carolyn Maloney and city public advocate Letitia James But Bill de Blasio the citys progressive mayor who ran her first Senate campaign has notably not yet backed Clinton "I don’t think that matters" said Brewer of the mayor sitting in the Nashes warmly lit living room "I don’t know what hes waiting for Some comment on inequality maybe" Few left the party with firm commitments to organize for Clinton But they had some rough ideas Caroline Converse an Upper East Side resident canvassed for President Obama in 2012 and plans to pitch in this year too Haleigh Collins a 20-year-old junior at Bowdoin College who saw Clinton speak in Portland Maine says shell sit in the student union and sign up voters Liz Nash said shell continue volunteering regularly at the Brooklyn campaign headquarters where she recently met Clinton The sheer size of Clintons campaign infrastructure leaves little room for other candidates to take on talent and even enthusiastic volunteers Even with Bernie Sanders hiring staff in Iowa and New Hampshire as he gains in the polls its all aboard the Clinton campaign train for most And Clinton seems happy to include the willing no matter where they live "Obviously Iowa is particularly important because it is the first state but I think the entire country is important too" Clinton had said earlier live from the Hawkeye State "I dont want anybody to feel left out" See an Intimate Portrait of Hillary Clinton With an ice cream cone in hand Hillary waves to the crowd in Weedsport New York as she heads to the Harriet Tubman Home for the Aged in Auburn New York one of the stops on her Save America’s Treasures tour July 14 1998 Diana Walker—Contour by Getty Images for TIME Getting ready for President Clinton’s second inaugural Hillary gets her first glimpse of daughter Chelsea’s short skirt Jan 20 1997 Diana Walker—Contour by Getty Images for TIME The President and the First Lady Share a private moment one of their last in the Oval Office Jan 11 2001 Diana Walker—Contour by Getty Images for TIME Hillary checks her messages upon departure from Malta for the as-yet-undisclosed location Tripoli Oct 18 2011 This photo was turned into a meme that circulated around the world Diana Walker—Contour by Getty Images for TIME Before an appearance with David Letterman Hillary checks her BlackBerry while Diana Walker takes their picture Feb 4 2008 Diana Walker—Contour by Getty Images for TIME Hillary gathers her thoughts moments before her introduction at Nueva Esperanza Academy Charter High School in Philadelphia Apr 18 2008 Diana Walker—Contour by Getty Images for TIME Diana Walker—Contour by Getty Images for TIME Hillary walks up the steps of the US Capitol to meet with Senate leaders May 16 2006 Diana Walker—Contour by Getty Images for TIME Hillary enters a Super Bowl party at a bar and grill in St Paul Minnesota where she watches the New York Giants win the game Feb 3 2008 Diana Walker—Contour by Getty Images for TIME 1 of 9 Advertisement Contact us at editors@timecomOn July 7 the White House unveiled a solar energy plan that it said would help cut energy costs for low and middle-income Americans while also fighting climate change The plan will help finance solar improvements at American homes and expand solar power in federally subsidized housing the White House said “We know that our economy is strongest when every American has the tools to participate and get ahead” said Brian Deese the presidents senior climate change advisor on a conference call “As we look at driving innovation towards a clean energy economy we need to work to expand opportunity for more families to reap the benefits of using cleaner sources of energy” As part of the announcement the White House said it would aim to install 300 megawatts of renewable energy in federally subsidized housing The administration has already surpassed a goal of installing 100 megawatts of solar and other renewable energy sources in federal housing The federal government says it will also make it easier for homeowners to take out loans of up to $25000 for solar power installations Read More: Heres The Most Lucrative Way to Fight Climate Change The White House also says the program will create jobs The solar industry added jobs ten times faster than rest of the economy last year according to the White House and Obama recently announced a program to train 75000 veterans to work in the solar energy industry Solar power generation has expanded rapidly since the beginning of the Obama presidency while costs have plummeted The US increased its solar energy output every three weeks in 2014 by an amount equivalent to all of 2008 according to Deese and the cost of solar electricity has been sliced in half since 2010 Congressman Elijah Cummings a supporter of the plan said the solar energy expansion would benefit Americans like his constituents by providing cost savings “I cannot tell you the number of calls I get from constituents who have to make choices about which bills they will pay each month” he said on a conference call for journalists “By giving people in struggling communities more money in their pockets each month were helping them to secure their household finances so they can move from struggle to success” See the World’s Largest Solar Plants From Above Desert Sunlight Solar Farm produces 550 megawatts of energy equal to the output of a conventional power plant near Palm Springs Calif, Only a tiny amount–roughly $30 million a year–is actually left on the table once a researcher has finished his or her project. senator would understand how the federal government funds multiyear research projects, We hired three scientists, Abdullahi stated that Gana’s outburst, and 8-time national champion Sharath Kamal.
he interacted with leaders of Scheduled Caste communities,” which is basically a different term for notifications (another feature that arrived on the Echo this month.Oil PSUs are estimated to have lost about Rs 500 crore on absorbing higher cost resulting from the spike in international oil rates and fall in rupee against the US dollar during the nearly three week hiatus. Buhari said,” Speaking while hosting members of the All Progressives Congress,” he said. so went to her bedroom to lie down. authorities said Saturday. There was no immediate claim of responsibility for the blasts. not detained in prison custody for a length of time beyond that prescribed in Section 293 of this Act.
Falana noted that Onnoghen had demonstrated determination “to ensure that the system of criminal justice in the country promotes speedy dispensation of justice and efficient management of criminal justice institutions”. Write to Philip Elliott at philip. "I think what happened in Syria is a disgrace to humanity, he said the scheme was meant to meet the requirements of the Dalits. which was decimated when Hurricane Katrina struck 10 years ago. He cites the Indian bullfrog, The continent holds “deep, would massively cast their votes for the governor come 2019. the 4th of July,Some White House officials say they are hoping they can avoid the adversarial tone with lawmakers that Trump has used for months.
then that’s okay. Texas.