Categories: News,Tedder News State Rep. Jim Tedder today applauded the passage of the FY 2017 General Fund and School Aid budgets, calling them fiscally responsible and good for all students of Michigan.“As it has been in the past few years, we got the budget done far ahead of schedule,” said Rep. Tedder, R-Clarkston. “We’re increasing funding to education on all levels, making strides in infrastructure repairs and supporting veterans and first responders.”Rep. Tedder serves as the vice chair of the Committee on Workforce and Talent Development. He is also a member of the Committees on Education, Health Policy, and Communications and Technology.“I am most happy about the work that went into the school omnibus budget,” Rep. Tedder said. “We fought hard for the boilerplate language intended to improve services to the Oakland County Mental Health Authority. We also expanded the Healthy Kids dental program to under served children in Oakland County, as well as increased funding for adult foster care facilities for seniors.” 09Jun Rep. Tedder praises FY 2017 budget
All of our lives have occurred in an era of peak somnambulism (a.k.a. sleepwalking), and those of us who enjoy being awake have suffered mightily because of it. Using your mind has come with a price in our time, which is pretty sick, really. You can thank growing government tyranny for that. Humanity, however, does not sleep forever. Eventually humans get tired with the permanent suspension of thought. I know that none of us have ever seen that in our lifetimes, but I study history, and trust me, it has happened in the past. Can you imagine people traveling a hundred miles on foot, over muddy roads and fields, with bad shoes, and sleeping outdoors, just to listen to a teacher who the authorities had recently defrocked for immorality and cast out of the city? And this teacher wasn’t a religious guru or the leader of a revolution: he was teaching things like history, philosophy and logic. Well, hundreds of people, even thousands, did this in the early 12th century. (The teacher’s name was Peter Abelard, and he wasn’t the only one.) Europeans had been cut-off from learning by their ruling systems for hundreds of years, and yet at this moment they remembered that they were human and woke up. I’m promising that this will happen again anytime soon, mind you, but it does happen on occasion. History Shows the Way From the 12th century through the 19th century, Europeans and Americans generally used their brains, and life in the West improved massively; far beyond anything ever seen in the historical record. But then, it changed. Knowledge didn’t go away, but humanity forgot that it mattered and decided that sleepwalking was easier and better. It’s not often that you get personalities as diverse as F.A. Hayek, Virginia Woolf, Ayn Rand, and the Bohemian artists of London to all agree, but there was one subject on which they did concur: All of them said that there was a distinct change in the nature of humanity in 1911 or thereabouts. Virginia Woolf, for example, was very precise, placing it in December of 1910 and writing that “human character changed.” Ayn Rand, who was very young at the time, placed it “before World War One” and said “the West lost its nerve.” Whatever it was that happened, it is very clear that since that time, the men of the West have tried very hard to sleep and have fought to remain in their slumbers. Yes, they were scientifically trained to be that way in government conditioning centers (a.k.a. schools). And yes, they spent decades of their lives in factories where thinking was taken as a threat. And yes, it’s true that they were subjected to millions of advertisements that grasped at their minds and wills. But even all of that doesn’t account for a hundred years of slumbers. There’s a Reason it’s Called the Idiot Box… The big factor in all of this was the great god of the age: Television. After all, to most people, television is simply what we do. Try telling people that you don’t watch TV some time and see what happens – they’ll treat you like a space alien. And if you persist, they’re likely to see you as a threat. TV is simply what modern humanity does. Americans watch better than 150 hours of TV per month these days – on average. And when they’re not watching flashing images on their awesome new flatscreen (bigger than their neighbor’s!), they’re plugged in to some kind of iPod, iPad, or some other trendy new iGadget. Anything to avoid thinking. And the more bizarre the world gets – like Presidents and courts agreeing that droning citizens to death without a trial is not a Constitutional problem – they more they avoid thinking. The more the need to think sits in front of their faces, the more they crawl into TV, music, tabloids, booze, and anything else that will allow them to avoid it. Their ignorance must be preserved, or else they’ll have to face the thing they’ve been running from all their lives: responsibility. But, as I say, this will not last forever. Whenever it is that the hypnosis breaks, those who have been using it as a slave drug will have a problem. And that may be why they’re in such a hurry to build a fast, cheap tyranny. Once humanity turns again, the elite life-skimmers will need the ability to remove troublemakers quickly and easily, and to lead with it on the nightly news… presuming that anyone still watches the insulting drivel. There are signs of humanity waking up, after all. Who would have dared to predict thousands of young people following an old doctor like Ron Paul around the country, eagerly waiting to hear about the Federal Reserve scam? I’m not at all sure that will be enough, but it did involve numbers of young people opening their eyes, and it was a real surprise. Government Tyranny in Action So, if this continues, the power-mongers will need cheap control, which is why they’ve been procuring drones and computers. Drones and 24/7 monitoring make for excellent, cheap tyranny: A world-wide surveillance web to see what you are thinking about, a world-wide manipulation system to nudge you in the ‘right’ directions, and drones to intimidate you… and, if necessary, to take you out. (Once your worst texts and emails have been worked into an appropriate story, of course.) So, we’re in a race between cheap government tyranny, and humanity deciding that a hundred semi-comatose years were enough, and that it’s time to wake up. Which side will win the race? I dunno. Paul Rosenberg FreemansPerspective.com
A consultation event set up by MPs to produce recommendations from members of the public on the future funding of adult social care has failed to ask any disabled people’s organisations (DPOs) to provide them with “expert” opinions.DPOs have raised “deep concerns” about the way the Citizens’ Assembly on Social Care has been organised, and its failure to ensure that disabled people and their user-led organisations will have the chance to influence its conclusions.The assembly will take place in Birmingham over two weekends, 27-29 April and 18-20 May, with up to 50 members of the public brought together to consider the best way to fund adult social care in England.It is part of an inquiry into the long-term funding of adult social care being carried out by the Commons committees on housing, communities and local government and on health and social care.But although the members of the Citizen’s Assembly will “reflect the wider community” and will include disabled members of the public who are users of social care, there are no DPO representatives among the “expert lead”, advisory panel and expert contributors who will address the Citizen’s Assembly on the first weekend.Those experts set to address or advise the assembly include representatives of Mencap, Policy Exchange – the centre-right thinktank co-founded by government minister Michael Gove – Carers UK, Alzheimer’s Society, Reform (another centre-right thinktank), the Local Government Association, and – possibly – the Centre for Social Justice (founded by former work and pensions secretary Iain Duncan Smith).There will also be a representative of the Care and Support Alliance (CSA), a network of almost exclusively non-user-led charities, but she also works for Alzheimer’s Society.The event has been organised on the committees’ behalf by the charity Involve.The Citizens’ Assembly’s findings will be published on the committees’ websites this summer, and its findings will be considered alongside other evidence submitted to their inquiry.The inquiry’s conclusions are set to be published ahead of the government’s planned social care green paper.After being contacted by Disability News Service, the event’s organisers approached Inclusion London, a leading DPO, to ask it to take part, but only on the second weekend and only as part of a panel that will be asked to give “the wider social and political context of social care in England”.Professor Peter Beresford (pictured), co-chair of the national service-user network Shaping Our Lives, said the “list of so-called experts and advisers is a list of the usual suspects”.He said: “Where are the disabled experts, the mental health service-user experts, people with learning difficulties experts, etc?”He said citizens’ assemblies had “well evidenced limitations” and “tend to reflect the usual exclusions and biases of mainstream society”.He said: “This is a top-down initiative, so from the start it is difficult to see how they will reflect the concerns of the diversity of social care service-users and disabled people.“Of course, there might be an argument for such a body if there weren’t local and national user-led organisations which have already made clear what they think is needed for social care: a service offered on the same terms as the NHS, committed to supporting the philosophy of independent living.” He said the “predictable result” of the assembly would be “a safe mess, but a costly and wasteful one.“We actually already have the evidence for decent social policy, [but we also have] an ideological and political unwillingness to take any notice of it on the part of this crumbling government.”Linda Burnip, co-founder of Disabled People Against Cuts, said: “We are deeply concerned about the Citizens’ Assembly that is taking place on the future funding of adult social care.“Any attempt to involve the voices of grassroots disabled people has been very last minute and yet social care is an issue that is having a very immediate and detrimental impact on our lives.“Assembly members are ‘asked to make trade-offs and arrive at workable recommendations’, but without the views and interests of adult social care users at the heart of the process, we are concerned that those recommendations will not reflect the best interests of disabled people, yet through the assembly formation they will attain cross-party legitimacy and be seen to represent an electable policy on social care.“What we need are politicians who are not afraid to stand up for bold solutions that will protect disabled people’s rights to independent living and to equal participation in society.”Tracey Lazard, chief executive of Inclusion London, said: “Inclusion London welcomes the opportunity to speak about the wider social and political context of social care in England at the second weekend of the Citizens’ Assembly.“We are disappointed that there hasn’t been greater engagement of Deaf and disabled people’s organisations and that the organisers have worked predominantly with charities to shape the assembly and select speakers.“However, it is important for us to take this opportunity to put across the urgency of the situation facing disabled people who need social care support and to ensure that the needs and interests of disabled people of working age are heard.”Sue Bott, deputy chief executive of Disability Rights UK, also said she believed there should have been representatives of DPOs among the advisers.She said: “I’m sure such an assembly will make a useful contribution to the debate but the way in which it has been set up means that it can only ever be a partial contribution. “I have no doubt that the advisory panel have a great deal of experience on the workings of care funding but what is missing is the expertise on the impact of care costs on individuals and their life chances. “For that you would need to include, as advisors, representatives of people using social care services and their organisations.”Brian Hilton, digital campaigns officer for Greater Manchester Coalition of Disabled People, said: “The fact that the voice of disabled people’s organisations are not represented on the advisory panels diminishes both their legitimacy and the knowledge base they draw upon on the important issue of social care funding.“It also calls into question whether it was simply an oversight not to seek the involvement of DPOs, which is alarming in itself, or even more worryingly, is it that the knowledge, skills and experiences of disabled people are simply judged to be of no importance?”A spokesman for the committees and Involve said the “recruitment criteria” for the expert panel had been “to ensure that the assembly’s plans and materials are factually accurate, comprehensive, balanced and unbiased”.He said: “The Citizens’ Assembly on social care is considering alternative options for funding social care in the long term – for example taxation and insurance-based models.“The first weekend covers different funding mechanisms, so speakers have been recruited for their specific expertise and perspectives on particular models.”He said that recruitment of speakers for the second weekend was “beginning this week” and would be announced after the first Citizens’ Assembly weekend.The second weekend will begin with a panel giving “the wider social and political context of social care in England”, and he said they were “approaching speakers from a user-led disability organisation for this”.He said that CSA, which was “an umbrella organisation which includes DPOs”, had “been supportive in helping us shape the Citizens’ Assembly, including its advisory panel and speakers”.He said that a CSA representative was contributing to the first weekend of the assembly, but when it was pointed out that that representative worked for Alzheimer’s Society, which is not a DPO, he declined to comment further.Citizens’ assemblies have been used in the UK and in countries such as Australia, the US and Canada – with one currently taking place in Ireland – and aim to give members of the public the opportunity to learn about and discuss a topic before reaching conclusions, with members “asked to make trade-offs and arrive at workable recommendations”.
April 12, 2018 Leading Your Company Forward in These Tumultuous Times Next Article The only list that measures privately-held company performance across multiple dimensions—not just revenue. Apply Now » 2019 Entrepreneur 360 List –shares Opinions expressed by Entrepreneur contributors are their own. Culture Shift Add to Queue 4 min read Larry Senn Image credit: Thomas Barwick | Getty Images A shifting power base in a polarizing political climate is changing the landscape of leadership. How do you garner trust, create a culture of accountability and ensure a healthy and productive workplace? Old business models are experiencing tectonic shifts across all industries. Retail is shrinking as online grows; Airbnb and ride-share services are changing how we think about assets like cars and real estate. Artificial intelligence, digital transformation, increased transparency and fading hierarchy are shifting the base of power in business. It’s all changing.There’s a shifting social consciousness, too. The #metoo movement and the rise of the millennial workforce mean new and important conversations are taking place. If it we didn’t believe it before, we now know it’s true: A leader’s personal behavior has a critical impact on business. Whether you are a disruptor or the disrupted, whether you’re directly implicated in a headline-grabbing crisis or merely stuck in a culture that’s no longer serving you or your mission, now is your opportunity. How can you harness the zeitgeist and use it for positive change?You have to own it.It’s not a new idea, but it’s one we don’t always acknowledge — organizations become a shadow of their leader. Whether you have two or 20,000 employees, culture change has to start at the top and be authentic. Simply endorsing a certain set of values is not going to work. You must embody and model them on a daily basis. Period.Related: Company Culture Comes From Good LeadershipIt might get uncomfortable. Owning culture change means getting vulnerable about what you need to work on at a personal level. No one is immune. The good news is that vulnerability is powerful: It fosters trust within the organization, all the way down to employees you may never see or connect with.“Culture eats strategy for breakfast,” management guru Peter Drucker famously once said. That is even more relevant today. Leaders have always needed what were thought of as “soft skills,” but some resisted. It didn’t fit an “ivory tower” mythology. Today’s leaders understand that culture is a strategic imperative.Anger is out — gratitude is in.At its simplest, gratitude is a decision, a mindset that looks for the positives in any situation. Studies say gratitude improves well-being, creates happier relationships and even prevents disease. Professionally, gratitude fosters better ideas, ups creativity and collaboration, increases focus and productivity and improves morale.Related: Why Entrepreneurs Should Always Express GratitudeAnger, self-righteousness and judgment create a downward spiral that leads, at best, to distraction and impatience. Next time you feel your blood pressure rising, take a deep breath, and then take a long walk. And watch not only your own effectiveness improve, but also that of those around you.The kids get it.Whether you’re a millennial or Gen Z or recruiting them, you recognize it’s not business as usual with the next generations. Self-actualization is huge for this rising workforce that wants to be included, recognized and inspired by their work. You don’t have to be a nonprofit to create a spirit of social consciousness at your organization; just tap into the issues your employees and customers care about, and they will lead the way.Related: 5 Reasons Why Sustainability and Social Issues Attract CustomersThe exciting thing about culture change is the potential it has to propel us toward something greater and build more resilience into our enterprise. A healthy culture has agility hardwired into it and can flex to meet the challenges of a rapidly changing marketplace. It can also position you to attract highly skilled employees and better investors.The demand for more transparency than ever from the companies we choose to do business with, customers are waking up to the idea that they can reward companies that lead with integrity. The best employees typically want to work for companies that are highly regarded in the marketplace. Reputational gains and employee engagement are other positive outcomes of a healthier culture.Don’t wait for the shifting sands of change to define you. Take your success, and that of your company, personally, and grow yourself into the type of leader that casts a long and positive shadow. Guest Writer Author, “The Mood Elevator”
Founder and CEO, CircleUp Next Article Opinions expressed by Entrepreneur contributors are their own. Add to Queue In one month, we will profile the winners on Entrepreneur: The 25 most innovative consumer and retail companies. These brands are changing how we live our lives — from apparel, food, household products to personal care. Learn how to successfully navigate family business dynamics and build businesses that excel. Innovation Guest Writer June 5, 2014 3 min read Who Are the 25 Most Innovative Consumer Companies? –shares Who are the most innovative consumer and retail companies? CircleUp wants to hear your nominations. Please tweet your suggestions using #CircleUp25, post your nominations on your Facebook page with #CircleUp25 or post to our Facebook page. Nominations and votes will be collected until July 2. Ryan Caldbeck Top consumer private equity firms and leading consumer investment bankers; The largest public consumer companies, many of which are potential strategic acquirers; The most well-respected consumer trade publications; National retailers with access to their own proprietary data; Successful consumer entrepreneurs; Third party data providers analyzing industry trends; and Consumer angel investors. While we hear about technology innovations every day, we often hear less about innovations in consumer and retail — even though it comprises more than 20 percent of the U.S. economy. We want to take this opportunity to celebrate these innovations that touch our everyday lives. We will profile companies that are disrupting industries or creating new categories. New formulas, design of the product or packaging, or disruptive marketing — each of these might help a company earn a spot on the list. Related: Apple Tops List of World’s Most Innovative Companies … AgainThe only criterion are that the company must be private, have not been on the CircleUp25 list in the past, and have no connection, at the time the list is published, with the accredited investor crowdfunding site that I founded. While I believe there are companies that have raised funds with us that deserve a spot on the list, they are excluded from participating to avoid a conflict of interest.In the spirit of crowdfunding, we want to hear from you — the consumers, investors and entrepreneurs behind many of these businesses. Who are the companies making the greatest impact in the consumer space right now?Related: Crowd-funding Platform Connects Entrepreneurs With Consumer-Product GiantsYour nominations will be judged based on audience participation and voting as well as feedback from a panel of experts who will review all the candidates to help determine the final list. The panel has also submitted additional nominations. This panel includes: Free Webinar | July 31: Secrets to Running a Successful Family Business Look out for the official list of the 2014 CircleUp25 on Entrepreneur.com around mid July.Related: Why Startups Should Still Care About Things That Don’t Scale Register Now »
Writer 2 min read Technology Learn from renowned serial entrepreneur David Meltzer how to find your frequency in order to stand out from your competitors and build a brand that is authentic, lasting and impactful. Fireside Chat | July 25: Three Surprising Ways to Build Your Brand Image credit: Microsoft Research Timothy J. Seppala This story originally appeared on Engadget March 28, 2016 Add to Queue Last June Microsoft showed off its HoloLens tech that created holograms from live video. Now it’s putting that into practice and giving it an official name: Holoportation.It uses multiple 3-D cameras to capture a subject from all angles, creating a “temporally consistent model” that can mimic the feeling of someone being in a room with you. During a TED Talk, Alex Kipman used it to virtually meet with a colleague in front of a Mars backdrop, but this lab demo from Microsoft Research shows something a bit more realistic. That is, so long as you’re wearing one of the $3,000 augmented reality headsets.The setup is in an incredibly controlled environment (the remote location and where the video hosted by Microsoft Research’s Shahram Izadai are laid out pretty similarly), but it definitely shows the potential of using the device as a means of long-distance communication. You can even record a portion of a holoportation session and play it back, shrinking it down to size to fit on your coffee table. It’s pretty neat! But it’s still incredibly early. Artifacts resulting from compression or motion tracking are still present, a reminder that this is still a prototype, and break the illusion a bit.Check out the picture-in-picture shots and you’ll see the somewhat flickery and translucent images that go part and parcel with the headset at this point. Despite that, it’s hard to not get at least a little excited for a future where real-time holographic meet-ups with a loved one (or a zombie) exist. Next Article With Microsoft Tech, You Can Talk to a Hologram of a Co-worker or Friend…or Your Mom –shares Enroll Now for $5
Chuck HuangCITCONfundingMarketing Technologymobile paymentNewsSeries B financing Previous ArticleEarth Day Network Partners with Twitter to Release ‘Earth in Our Hands’ Emoji to Mark Earth Day 2019Next ArticleRFPIO Leads Way to Faster, More Accurate Responses with Patented Document Import, Export Functionality East West Bank Leads the Series B Funding Round as a Strategic InvestorCITCON, the leading cross-border mobile payment and commerce solution provider announced that it has raised US$5 million from East West Bank as its strategic investor for the Series B financing round, bringing the total financing to US$15 million to date. The funds will be used to drive the company’s rapid global growth, broaden its suite of product applications and expand teams across Technology, Product, Marketing and Sales. East West Bank joins a group of investors that include Zhen Fund, HEDA Capital, Cyber Wisdom, Lightbridge Ventures and TEEC Angel Fund. Catherine Zhou, Executive Vice President and Head of Consumer Banking and Digital Banking at East West Bank, will join the company’s Board of Directors.Founded in 2015, CITCON introduced China’s largest QR-based mobile wallets Alipay, WeChat Pay, and UnionPay to North America, and has quickly grown into a dominating market leader of QR-based cross-border mobile wallet solutions, connecting global merchants with billions of Chinese consumers across Retail, Hospitality and eCommerce segments, integrating cross-border payments, marketing and eCommerce solutions. Over the last 12 months, the transaction volume and merchant base has grown 10 times and is expected to reach 50,000 merchants by the end of 2019 across all major metropolitan cities in the United States, Canada and Europe.Marketing Technology News: Outreach Recognized as an April 2019 Gartner Peer Insights Customers’ Choice for Sales Force Automation“In the past few years, mobile wallet and mobile payment have profoundly changed how merchants interact with consumers, and the digitization of all walks of life has continued at a rapid pace,” said Chuck Huang, Founder and CEO of CITCON. “The China market has been a growth engine for global brands. Adapting to the change and implementing industry leading and customer favored solutions has become a necessity for merchants to capitalize on the growing demand from the market. The strategic investment by East West Bank is a testament to our vision to transform the multi-trillion-dollar digital payment system into an omnichannel mobile payment and commerce system on a global scale.”East West Bank, a wholly owned subsidiary of East West Bancorp, is one of the largest independent banks headquartered in California and operates over 130 locations worldwide. The bank ranks among the 25 largest publicly traded banks in the US by market capitalization.Marketing Technology News: CoreMedia Partners with Zilker Technology to Provide Roadmap to Help IBM Customers Optimize eCommerce Investments“As a premier bank focused on the United States and Greater China markets, we are committed to serving our customers’ cross-border needs, and this investment will further accelerate our commitment,” said Dominic Ng, Chairman and CEO of East West Bancorp. “Prior to the investment, East West Bank and CITCON had formed a partnership which gives our business customers access to CITCON’s mobile payment solutions. We believe the future of commerce will be driven by mobile technologies, and our alliance with CITCON will fuel positive growth opportunities for our customers.”“On the consumer banking front, East West Bank is striving to provide our consumers around the world with a comprehensive set of solutions that connect with their lifestyle and meet their needs,” said Zhou. “Rapidly evolving consumer behavior, coupled with the continued growth of fintech solutions, provides an unprecedented opportunity for us to create a unique next-generation mobile platform. We are excited to be part of the journey with CITCON.”Marketing Technology News: 3CLogic Announces Microsoft AppSource Certification for Microsoft Dynamics CRM CITCON Raises US$5 Million to Power Global Expansion of Mobile Payments PRNewswireApril 24, 2019, 5:51 pmApril 24, 2019
Our research has again highlighted the urgent need for making the programme more patient-focused. We want to see self-sampling being made available as well as more flexible locations for women to attend. It is vital women have more control otherwise we will see attendance continue to fall and diagnoses of this often-preventable cancer increase.”Robert Music, CEO, Jo’s Cervical Cancer Trust By Sally Robertson, B.Sc.Jan 21 2019Reviewed by Kate Anderton, B.Sc. (Editor)A UK survey of more than 2,000 young women has shown that many delay or avoid having a smear test due to feeling scared, vulnerable, embarrassed or not being in control. Image Point Fr | ShutterstockThe survey, which was conducted by Jo’s Cervical Cancer Trust, also revealed that many women are put off by the thought of being examined by a stranger.Current estimates show that cervical screening rates are at the lowest they have been in two decades, with around one-third of women aged between 25 and 64 not complying with the NHS recommendations that women aged 25 to 49 have a smear test every three years and those aged 50 to 64 have a test every five years.Jo’s Cervical Cancer Trust is now launching a campaign #SmearForSmear as part of the Cervical Cancer Prevention Week (running from 21st to 27th January) in an effort to address the decline in screening rates and recognise the wide range of new issues that seem to be contributing to the problem. Smear tests provide the best protection against cervical cancer yet we know they aren’t always easy. We want women to feel comfortable talking to their nurse and asking questions. It’s not making a fuss and there are many ways to make the test easier. Please don’t let your fears stop you booking a test.”Robert Music, CEO, Jo’s Cervical Cancer Trust Source:Smear test fears causing hidden health crisis for Millennials The survey data revealed that of 2,005 women aged 25 to 35, almost half (46%) regularly delayed or avoided taking up their invitation to have a smear test. The reasons those women gave included feeling scared (71%), vulnerable (75%), embarrassed (81%) or as if they would not be in control (67%).When asked what led them to miss or delay a test, 69% said the thought of having an intimate area examined by a stranger made them feel uncomfortable; 58% said they feared pain and 31% said they were unaware what the test would entail.The data also revealed that almost 30% of the women would feel awkward asking the nurse to stop or saying the procedure was hurting, 18% would feel uncomfortable asking what the nurse is doing, and 19% would not share their concerns with the nurse.
Reviewed by James Ives, M.Psych. (Editor)Feb 28 2019Advances in genetics and genomics have taught us that every single tumor is different, and yet most standard therapies treat them all in the same way, limiting the effectiveness of treatments offered to many cancer patients.In recent years, exciting advances have resulted in an emerging range of immunotherapies that broadly stimulate the patient’s immune system to fight cancer. These treatments artificially inhibit the natural ‘braking’ system in the body’s immune system to allow it to target antigens produced by the tumor – those originating from mutations in the cancer.But many people are not yet able to benefit from these cutting-edge treatments. This is largely because many types of cancer have a low number of genetic mutations, meaning that they produce only a few antigens – structures that can be targeted by the body’s immune system.The EU-funded GAPVAC project undertook the first clinical trial to design and manufacture actively personalized vaccines (APVACs) – a new type of immunotherapy approach, unique in that it is much more closely tailored to the characteristics of each patient’s immune system and their specific tumor than existing treatments.GAPVAC researchers targeted glioblastoma – an aggressive brain cancer – because conventional therapies are largely ineffective, cause unpleasant side effects, and are not at all personalized. The five-year survival rate for this cancer is currently just 6 %.’When we conceived the idea of the GAPVAC trial years ago, people said it was logistically close to impossible,’ says project coordinator Norbert Hilf of Immatics Biotechnologies in Germany. ‘The complexity of the processes involved and the translation of such a concept into the clinical setting was unprecedented.’Pioneering, personalized treatmentIn December 2018, the team published the results of the GAPVAC trial in Nature, revealing that the phase 1 study had successfully demonstrated promising clinical courses as well as the safety and feasibility of precisely tailoring immunotherapy to the characteristics of patients’ individual tumors and immune systems.Fifteen patients with glioblastoma took part in the trial, with GAPVAC researchers analyzing each tumor’s specific mutations, its molecular make-up, and each patient’s ability to mount an immune response.Related StoriesHow cell-free DNA can be targeted to prevent spread of tumorsResearchers report how a popular antidepressant drug could rewire the brainStudy offers clues about how to prevent brain inflammation in Alzheimer’sMost patients were given two different vaccines – APVAC1 and APVAC2 – starting at different times. Like all cancer vaccines, they aimed to stimulate T-cells in the patient’s immune system to attack the tumor.The APVAC2 vaccine was composed predominantly of antigens unique to each patient, mainly peptides – short chains of amino acids – carrying mutations highly specific to their tumor. These antigens had been identified through next-generation DNA sequencing and individually manufactured for each patient – a process which takes about six months and is relatively expensive.The APVAC1 vaccine, however, was designed using a ‘warehouse approach’ that lies somewhere between off-the-shelf vaccines and tailor-made mutated antigens as used for APVAC2.GAPVAC researchers pre-manufactured over 60 peptides identified to be highly relevant antigens, in many cases, for glioblastoma and incorporated them into vaccines, creating a mixture of up to 10 antigens for each patient. The advantage of this approach is that it can be delivered more quickly and cost effectively than APVAC2 which requires fully personalised vaccine manufacturing.Although the sample size was too small to claim any clinical effects on the patients treated, the survival data were encouraging, and both vaccines drove excellent immune responses in the patients. Researchers also found vaccine-induced immune cells exactly where they were needed – in the tumor of a patient.Blueprint for the futureThe GAPVAC project has been vital to developing the concept and processes behind the active personalisation of cancer treatment. Following in its path, the partners of the GAPVAC consortium are undertaking further steps in the development of tailor-made immunotherapy. For example, the coordinating company, Immatics, has used GAPVAC as a blueprint for its ACTolog trial – an adaptive cell therapy that employs the active personalisation concept.’The GAPVAC trial can be seen as a blueprint for personalised therapy concepts in general,’ says Hilf. ‘We’re currently discussing follow-up projects to further improve the magnitude of the immune response and to shorten the process time.’ Source:http://ec.europa.eu/research/infocentre/printversion_en.cfm?id=/research/headlines/news/article_19_02_27-1_en.html?infocentre&item=Infocentre&artid=49930
Apple CEO Tim Cook acknowledged that iPhone sales in the past quarter would be disappointing, amid weakness in China and other emeging markets “Apple stock is now at a crossroads,” said a research note Thursday from Gene Munster and Will Thompson of the investment firm Loup Ventures. Apple’s troubles in China come with the Chinese smartphone maker Huawei targeted in the United States over security issues Apple said iPhone sales in China would be lower than forecast due to steeper than expected “economic deleration” “Some investors will consider the stock broken.. but we’ve followed the company long enough to know there is cyclicality in the market’s relationship with Apple.”Munster and Thompson said it would take “a new product category,” or large acquisition to allow Apple to regain its momentum.Tactical errors?Some analysts said Apple erred in boosting the price of its new iPhones to well over $1,000 in a global smartphone market that is largely saturated and facing tougher competition.”I think the main villain is the very high prices that Apple is charging for its new iPhones,” said Richard Windsor, a technology analyst who writes the Radio Free Mobile blog.”This is not a catastrophe nor is it a sign that Apple is losing its grip on the smartphone market but merely a misjudgment by Apple with regard to how much money people will pay for an iPhone.” Apple has sought to diversify its revenue base with new products like its smartwatch and a range of services but still relies heavily on the iPhone This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Apple’s bombshell and the trillion-dollar question Apple’s bombshell news—a sharply weaker revenue outlook and lower iPhone sales—has raised questions over the future of the California giant, which until recently had been seen as the undisputed innovation leader in the tech sector. Citation: Apple’s bombshell and the trillion-dollar question (2019, January 4) retrieved 17 July 2019 from https://phys.org/news/2019-01-apple-bombshell-trillion-dollar_1.html The latest news sparked talk of the “Nokia moment” for Apple—a reference to the Finnish-based firm that led the mobile phone market in the early 2000s.But Windsor said: “I do not in any way think that this represents Apple’s ‘Nokia’ moment simply because there is still nothing to seriously challenge the iPhone in the high-end segment.”Carolina Milanesi of Creative Strategies said Apple is unique among smartphone makers because it has a wide array of apps and services that produce revenue.”While it is true that no other single product has done for Apple as much as the iPhone, the product offering as an aggregate still puts Apple ahead of all other vendors who might be selling higher volumes but have no direct way to monetize from their users once the sale has occurred,” Milanesi said in a blog.Patrick Moorhead of Moor Insights & Strategy said Apple may be unable to deliver the double-digit growth than many on Wall Street have been expecting given the current smartphone market.”I am not concerned for the company, but it’s likely investors will not see the company value it was at until it can see a likely path to double-digit revenue growth,” Moorhead said. Explore further Apple’s rare admission on Wednesday cited steeper-than-expected “economic deceleration” in China and emerging markets and noted that trade frictions between Washington and Beijing were taking a toll on its smartphone sales.But the news raised questions on whether Apple—the first to reach a $1 trillion valuation and until recently the world’s most valuable company—is seeing a bump in the road or is starting to slide back from its leadership position.Some analysts point to Apple’s dependence on iPhone sales to drive revenue and profits, even as it tries to diversify its product base and add services such as music and digital payments.”The iPhone has been supporting the company for than a decade,” said Roger Kay, analyst at Endpoint Technologies Associates.”The world isn’t coming to an end for Apple but it’s a major inflection point. Up to now, Apple has defied gravity by growing faster than any other company in the market, but mathematically it was impossible to beat the market forever.”Apple shares plummeted nearly 10 percent on the news Thursday, with the company shedding some 38 percent since its valuation hit $1 trillion last year. Kay said the trillion-dollar valuation was “irrational” and based on growth projections Apple is unlikely to achieve without a new catalyst.Apple, which has been growing in China even though it lacks a dominant position, is pressured by tariffs and other trade issues, further inflamed by the arrest of China-based Huawei’s chief financial officer in Canada at the behest of the United States.Huawei has overtaken Apple as the third largest global smartphone maker despite limited presence in the United States.’At a crossroads’The update suggested a disappointing figure for iPhone sales, the key driver of revenue and profit for the California tech giant.Apple said that it expects weak iPhone sales in other emerging markets, driving down revenue despite some positive signs in developed markets and in its other products and services.The company slashed its revenue guidance for the first fiscal quarter of 2019, ended December 29, to $84 billion—sharply lower than analyst forecasts averaging $91 billion. © 2019 AFP
The recent case of paper medical files from a Brisbane hospital found on a busy street highlights the need for secure, controlled disposal of medical records. So, hospitals and GP clinics need to develop and implement policies and procedures that state explicitly when and how medical records should be disposed of, and also keep a record of when that happens. However, to determine whether an individual medical record among the vast quantities held has passed its “use by date” can be extremely resource-intensive for administrative staff. This means the ultimate driver of paper record destruction is more likely to be the need to free up expensive office or storage space. It’s this sort of scenario that might eventually play out into records being accidentally or deliberately dumped wherever, whenever.The move towards digital recordsThe Brisbane situation highlights the limitations of “business as usual” in relation to medical records, which includes paper records held in multiple locations, in hospitals, in GP clinics and with specialists.Consider your own medical record “paper trail,” which may include files from hospital admissions, records held by your local doctor or other specialist, and results of blood tests and x-rays performed elsewhere. At both a personal and whole-of-population level, there are clearly numerous opportunities for unintended access to these physical documents. Centrally and securely stored electronic records can address this risk, and also carry a number of other advantages. Privacy breaches relating to paper medical records are in part a function of a worldwide transition from a trusted familiar environment of paper records to electronic medical records.This dramatically multiplies the volume of paper records needing to be destroyed —from only those that are “out of date” to every record that is scanned and made redundant.The Brisbane case also highlights the sensitivity of medical records in all their forms, a factor also playing out in the My Health Record debate.Who do we trust to keep our sensitive medical records safe? Should our trust be placed in the old paper records (part of the the status quo) or a centralized electronic medical record?The Brisbane situation, by highlighting the limitations of paper records, certainly challenges notions of trusting the familiar and favoring the status quo.So, what can we expect?Like all transitions of this scale, there are a range of costs involved in moving from paper to electronic medical records, one of which is the prospect of further paper record data breaches as mountains of redundant records are destroyed. However these transition costs need to be balanced against the ultimate benefit of electronic records. Even accepting these benefits doesn’t necessarily mean people will automatically become more comfortable with electronic medical records, like My Health Record. For that to occur, people also have to overcome a general lack of trust in government.However, our research shows it is possible to encourage people to use online government services. By harnessing behavioral science, we have shown that providing customer support and promoting the benefits and ease of online services helps the transition from queuing and paper forms to using online services.Hope for the futureIn the rush to drag people to shiny new online platforms, this illustrates the simple act of talking people through the advantages and supporting their transition can address many of the psychological barriers to change.Then, hopefully, we can see the end of paper medical records and services, and fewer paper records being dumped on the side of the road. As long as paper records exist they will be vulnerable to unauthorized access—either within a storage facility or in transit to destruction. However, each case of unauthorized access is dwarfed by the number of paper records successfully and securely destroyed, never able to be physically accessed again. This article is republished from The Conversation under a Creative Commons license. Read the original article. The files were said to be from out-patient clinics and contained patient names and their appointments, but not medical details. Now Queensland Health is investigating the circumstances of how the files came to be found in public, rather than being safely destroyed by a contractor.So how are hospitals and clinics handling their old paper records as they move to electronic systems? How are they dealing with the tsunami of files that need to be safely disposed of?Your medical records, whether paper or electronic, need to be kept while they’re relevant to your care, with restricted access to protect your privacy. But who decides when medical records are no longer needed? What happens then?Governments at all levels have legislation for this. For instance, the Queensland health department specifies what is destroyed and when, according to a schedule from Queensland State Archives. This covers medical records in the public health care system in physical form (paper, photographs, film), in electronic form or a mixture of the two.This, for example, says “records displaying evidence of clinical care to an individual or groups of adult patients/clients” should be kept “for ten years after last patient/client service provision or medico-legal action.” There are a number of exceptions relating to, for example, clinical trials, mental health and communicable diseases. For each exception, there is a specific time period of how long the file needs to be kept.Queensland State Archives also advises on how records are to be securely destroyed, either by shredding, pulping or burning.Hospitals can contract commercial services to destroy paper files. But the document owner, in this case the hospital, is ultimately responsible for ensuring this is carried out legally. The Royal Australian College of General Practitioners (RACGP) has established practice standards for GP clinics. These require the secure destruction (for instance, by shredding) of paper records before disposal. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. What to do with our old paper medical files now that records are going digital? As a recent Brisbane case demonstrates, not all files are heading straight for destruction. Credit: from www.shutterstock.com Citation: Paper tsunami: How the move to digital medical records is leaving us drowning in old paper files (2019, July 10) retrieved 17 July 2019 from https://phys.org/news/2019-07-paper-tsunami-digital-medical.html Provided by The Conversation Protecting your electronic health records Explore further
O’Connor last played for the Wallabies in September 2013.”It’s a clean skin from him to say ‘I just want to talk about rugby, if I play up you’ve got the right [to release me] – it’s not going to be an arduous process’,” Johnson said.”We’re not even talking about [the clauses]. He wanted them in. He wanted complete transparency to protect everyone because he was sincere of his wishes.”So it’s really good to have a lad forcing it to say, ‘Just believe me ’cause this is what I’m about’ and I go back to [the fact] that he’s a young bloke coming back who just wants to talk about rugby and be seen as a rugby player and we’re there to support him.”It’s a good statement for players accepting their responsibility for their career so he’s determined this and we’ve supported him on it.”O’Connor said of his decision to return to Australia: “The last time I returned (in 2015) I thought I was ready to repair some of the mistakes I made but also to I guess reach my rugby potential, but yeah, it was too rushed.”I didn’t recognise how much pain I was still in sort of mentally but in saying that I wouldn’t change it because that led me to meet some of the mentors I have in my life now and also the start of my journey of I guess understanding what my true self is and just what a privelege it is to play rugby.”I understand now that rugby is a gift and all I want to do now is use my journey back to inspire possibly other young men out there who are a bit lost in the world like I was.”Johnson added of discussions with O’Connor: “There were a lot of conversations and I needed to understand why he wanted to do this. It certainly wasn’t the money.”We saw the best of him as a young player. We’re hoping the sport allows us to really showcase what we’ve missed the last five or six years. O’Connor has been a controversial figure in the past and was released by the Reds in 2015 due to “personal issues”.He was later briefly suspended by Toulon for a drug offence, before signing for Sale Sharks.MORE: Christian Lealiifano, Scott Sio ruled out of Rugby Championship opener against SpringboksHowever, O’Connor has walked away from a lucrative Premiership deal to return to Queensland and, according to Rugby Australia director of rugby Scott Johnson, he has agreed to a contract that will ensure good behaviour. James O’Connor insisted on including behavioural clauses in his Rugby Australia contract in a bid to prove his new-found maturity. The 29-year-old has rejoined the Reds in Super Rugby, boosting his hopes of an Australia recall for the Rugby World Cup, and linked up with the Wallabies in South Africa for their Rugby Championship opener. “I genuinely believe in his sincerity about what he’s trying to achieve. I think it’s good for our sport if he comes back and plays well and is the man he really aspires to be.”The Wallabies team to face South Africa is set to be announced on Wednesday and O’Connor could yet feature.”He’ll certainly come into discussions,” Johnson said. “Whether this is the right time for him, we’ll wait and see.”
“Our biggest weakness is we don’t get the ball going into the paint consistently every night,” Clifford said. “So, we don’t get as many spot-up threes and we don’t shoot enough free throws, which are Markelle’s strengths, potentially. So, his fit, his strengths of what he can bring to our team obviously stand out.””We don’t have a timetable for when he’ll be back, but he’s really doing a good job.” @OrlandoMagic HC Steve Clifford gives @TermineRadio and @Jumpshot8 the latest on Markelle Fultz pic.twitter.com/N8gTv7rh3j- SiriusXM NBA Radio (@SiriusXMNBA) July 15, 2019Fultz began his career with high expectations after he was selected by the 76ers with the No. 1 overall pick in the 2017 draft. But, he has dealt with injuries and a hitch in his jump shot over the last two seasons, which have limited him to 33 total games.”Get right, and everything will take care of itself,” Fultz told The Athletic in March. “Nobody here is rushing me. Everybody here is just open to me getting right and healthy first.” “He’s working hard, he’s made great progress,” Clifford said. “You know, right now we don’t have a timetable for when he’ll be back, but he’s really doing a great job.Clifford said Fultz has the potential to make a major impact for Orlando on the offensive end. Related News Pelicans’ David Griffin thinks future of team is ‘crazy’ good The Magic still do not know when Markelle Fultz will play again.The 21-year-old guard has yet to play for Orlando after the team acquired him from the 76ers in early February in exchange for Jonathon Simmons and two draft picks. Magic coach Steve Clifford was asked about Fultz’s return to the court during a recent interview with SiriusXM radio. Russell Westbrook is ‘the most important player’ in Thunder history, Sam Presti says The Magic finished last season with a 42-40 record and made the playoffs for the first time since 2011-12. They fell to the Raptors in five games in the first round.Orlando re-signed Terrence Ross and Nikola Vucevic this offseason and inked Al-Farouq Aminu to a three-year deal, as well. The team also selected former Auburn forward Chuma Okeke with the No. 16 pick in the 2019 draft.
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