Adult Stem Cells Race Ahead; Embryonics Falter

first_imgMajor advances are being made with induced pluripotent stem cells (iPS), stem cells reconstituted from adult tissues, while interest in embryonic stem cells (ES) seems to be drying up.    Both Nature and Science reported advances in iPS technology last week.  Nature reported that the number of factors needed to reconstitute pluripotent stem cells has dropped from four to two.1  Science,2 reporting on another iPS study, said that the factors can be delivered without the need for retroviral insertion – one of the risks of the initial process announced last year (06/06/2007, 01/10/2008).    Meanwhile, things are looking bleak for embryonic stem cell labs.  Just a few years ago, all the major scientific organizations were pushing the US government to ease restrictions on human cloning so that America could keep up with the world’s gold rush of ES research.  Now, Andrea Gawrylewski blogged on The Scientist July 23 that biotech companies appear to be bailing on ES cells.  At first, investors jumped on the bandwagon.  “But with almost no therapeutic advances to show for the cash, the hype has died down.”  Now, investors are eyeing the iPS technology.  One analyst was quoted: “We’ve had advances in adult stem cells and [FDA] approvals.  Where do you think Wall Street money is going to go?”  Advanced Cell Technology, one of the early ES startups, is struggling to stay in business.Update 08/11/2008: Twenty lines of diseased cells have been created using iPS technology, reported Science Daily, making it possible for scientists to examine genetic disorders.  Science Daily also reported on the new ability to create iPS cells without the need for the cancer-causing retrovirus used in earlier methods.  The article said, “Researchers hope that such embryonic stem-cell-like cells, known as induced pluripotent (IPS) cells, eventually may treat diseases such as Parkinson’s disease and diabetes.”  In addition Nature News reported that skin cells from an elderly patient were transformed into nerve cells with iPS.  “It is the first time that an induced pluripotent stem (iPS) cell line has been created from a patient with a genetic illness,” Monya Baker reported.  “Like embryonic stem cells, iPS cells have the potential to develop into almost any of the body’s cell types and offer new disease insights.”    Meanwhile, Science3 reported new ethical worries about embryonic stem cell lines made available by the National Institutes of Health.  Egg cells were collected from donors without proper information and consent, the article explains: one firm told donors that cells “might be used in research,” and another told donors that the cells would be destroyed after a research project.  “Other forms failed to mention that embryos would be destroyed and that cells derived from them could end up in experiments around the world.”  One neurologist said “I was shocked” when she heard about the ethical lapses.  Most researchers “just assumed that the consent had been taken care of.”  Proposals to get retroactive consent from donors, though, will probably go nowhere.  The article ended by indicating that iPS technology might make embryonic stem cells superfluous, even though both presidential candidates (Obama and McCain) support expanding embryonic stem cell lines, as does Congress.1.  Kim et al, “Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors,” Nature 454, 646-650 (24 July 2008) | doi:10.1038/nature07061.2.  Aoi et al, “Generation of Pluripotent Stem Cells from Adult Mouse Liver and Stomach Cells,” Science, 1 August 2008: Vol. 321. no. 5889, pp. 699-702, DOI: 10.1126/science.1154884.3.  Gretchen Vogel and Constance Holden, “Ethics Questions Add to Concerns About NIH Lines,” Science, 8 August 2008: Vol. 321. no. 5890, pp. 756-757, DOI: 10.1126/science.321.5890.756b.Don’t forget how the Big Science community held President Bush hostage with claims he didn’t care for the disabled when he twice vetoed Congressional attempts to expand embryonic stem cell research.  Don’t forget how Hollywood tugged at our heartstrings with disabled celebrities begging for cures that could only come from ES cells.  Let this be a lesson about the trustworthiness of Big Science to make right choices on political and moral issues.  Meanwhile, can Californians get their $3 billion back after they were deceived into splurging on this morally-corrupt, dishonestly-hyped boondoggle? (11/03/2004, 02/08/2005, 10/13/2006).  Maybe after they get the Lottery removed.  Good luck.  The Lottery was similarly sold to voters as desperately needed for education.  Multiple editorials since have admitted that Lottery money doesn’t amount to a hill of beans in the school budget.  Meanwhile, a few lucky individuals get filthy rich for no admirable reason on the backs of millions of gullible individuals (who never learned math at public school) who are the least able to throw their money away.    Baloney detecting should be a prerequisite to entering a voting booth.(Visited 10 times, 1 visits today)FacebookTwitterPinterestSave分享0last_img read more

Three killed in Bihar over ‘buffalo theft’

first_imgThree people were beaten to death by a mob in Saran district of Bihar on Friday, alleging that they attempted to steal a buffalo, the police said. The families of the victims denied the allegation.Raju Nat, Bides Nat and Naushad Qureshi were attacked at Nandlal Tola of Pithauri village in the Baniapur police station limits in the early hours. Two of them were killed on the spot. Another died of injuries on the way to hospital, Superintendent of Police Har Kishore Rai said. He said two or three people have been picked up for interrogation.Deputy SP Ajay Kumar Singh rushed to the village as a clash erupted between the alleged attackers and the family members of the deceased. The relatives said the victims had gone out to relieve themselves when they were beaten to death.“We can say it with certainty that this is not one of those incidents of mob lynching. The animal allegedly being stolen was a buffalo. The attackers and the attacked belonged to the same social groups,” Mr. Singh said.Police have been deployed in the village, while people from both sides were at the police station to lodge complaints. The families of the victims “created a ruckus” at the Sadar hospital, where the bodies were taken for post-mortem, prompting police to use “mild force” to bring the situation under control, officials said.last_img read more

#InquirerSeven: Things to know about Jeff Horn

first_img2. He is an Olympian Pacquiao is usually given the de facto home court advantage, be it in Las Vegas or Dallas. This time, however, the Pacman will walk inside Brisbane’s Suncorp Stadium facing a hometown hero.Horn was born in Brisbane on Feb. 4, 1988 and has resided in his birthplace ever since.Come Battle of Brisbane, it’s safe to say that there will be more than 50,000 people in support of their boxing son.ADVERTISEMENT Both fighters are family men, and both also have lovable dogs.Quite some time ago, Pacquiao’s pooch Pacman reached headlines when it dogged the Filipino icon during his runs. According to the Sydney Morning Herald, Horn was called “gay” constantly during his growing up years.The verbal abuse held so much magnitude that the young Horn almost thought of suicide.“I got called ‘gay’ a lot. Words like that shouldn’t hurt me, but I was a kid. It cuts deep, especially when it’s every day. You don’t know how to stop it,” Horn told Sydney Morning Herald.“Day by day, it takes a bit of you. I know the lows you can feel. I’ve had those feelings, like suicidal thoughts. I can remember some days that I felt that because of the bullying.”6. Like Pacquiao, Horn also has a canine companion What ‘missteps’? Beneath his enigmatic identity is a man who battled demons en route to becoming a professor of the beautiful sport.Despite owning WBO and IBF’s secondary titles, Horn is still considered an unknown in comparison to the icons Pacquaio has faced.FEATURED STORIESSPORTSSEA Games: Biñan football stadium stands out in preparedness, completionSPORTSPrivate companies step in to help SEA Games hostingSPORTSMalditas save PH from shutoutSo to shine a little bit more of the spotlight on Horn, here are seven tidbits about the Aussie.1. Horn is Brisbane’s own son Cayetano to unmask people behind ‘smear campaign’ vs him, SEA Games MOST READ Sports Related Videospowered by AdSparcRead Next Robredo: True leaders perform well despite having ‘uninspiring’ boss PLAY LIST 02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games Juggling life as a schoolteacher and as a professional boxer can take a toll, and Horn does that looking for flushes, full houses, and pairs.As per Ring Magazine, Horn’s concept of a vice is playing poker. And that’s only his vice.Horn hasn’t forgotten his nerdy side as he regularly, according to The Australian, plays Monopoly every Saturday.He also likes to play a role-playing board game called Settlers of Catan. Horn, too, has a dog and it’s name is Lexie who, according to The Australian, likes to hang by Horn’s legs whenever the Aussie fighter watches television.7. Horn’s vice is poker Growing up, Horn wasn’t the fighter Australians now adore.He was the one wearing the glasses and playing board games and with such silence, Horn became a target of bullying.According to a story from The Australian, Horn was the victim of a lopsided beating when 30 bullies ganged up on him after school.Horn stood up against a bully, and what he got was a physical beatdown that changed his life.This harrowing experience led Horn to take up boxing and he’s then used that bullying episode every time he steps inside the squared circle.5. He got called ‘gay’ growing up LATEST STORIES Ross wins Best Player award; Rhodes top importcenter_img Horn’s pathway to professional boxing was his short, but memorable, run in the 2012 London Olympics.The Aussie had three fights in the London Games, taking dominating wins against Gilbert Choombe of Zambia, 19-5, and Abderazzak Houya of Tunisia, 17-11.Horn, however, fell to Ukrainian Denys Berinchyk, 21-13, in the quarterfinals.ADVERTISEMENT Horn holds a Bachelor of Education degree to teach secondary school from Griffith University and he’s also worked at a child care center.4. A victim of bullying Lacson: SEA Games fund put in foundation like ‘Napoles case’ Pagasa: Kammuri now a typhoon, may enter PAR by weekend Boxer Jeff Horn of Australia poses for a photo following a press conference with Manny Pacquiao of the Philippines in Brisbane, Wednesday, June 28, 2017. Pacquiao, is putting his WBO belt on the line Sunday, July 2, against the 29-year-old Horn. (AP Photo/John Pye)Australian pugilist Jeff Horn does not have the same notoriety as Manny Pacquiao’s previous opponents.Horn, whose “The Hornet” nickname gives him some semblance of flare, actually isn’t a typical run of the mill boxer.ADVERTISEMENT Don’t miss out on the latest news and information. China furious as Trump signs bills in support of Hong Kong Another vape smoker nabbed in Lucena LOOK: Jane De Leon meets fellow ‘Darna’ Marian Rivera View comments Pagasa: Kammuri now a typhoon, may enter PAR by weekend 3. He’s a teacher Horn has built an impressive boxing resume going undefeated, 16-0-1, and strapping himself with the WBO and IBF Inter-Continental welterweight titles.He’s also the no.2 welterweight under WBO and on July 2 has a chance to become the World champion as he battles Pacquiao (59-6-2).Outside of his expanding boxing career, though, Horn rolls up his sleeves and tightens his tie for his job as a high school teacher.last_img read more

Real Betis stun AC Milan with 21 win

Real Betis stun AC Milan with 21 win

first_img <a href=’;cb={random}’ target=’_blank’><img src=’;cb={random}&amp;n=a7617b59&amp;ct0={clickurl_enc}’ border=’0′ alt=” /></a> SharePrint AC Milan succumbed to their second defeat in five days after Real Betis triumphed at the San Siro in a Europa League encounter. The Spanish side broke the deadlock in the 30th minute thanks to Antonio Sanabria.Former Paris Saint Germain midfielder Lo Celso made it 2-0 with a long-range shot in the second half. Patrick Cutrone scored a consolation goal for Gennaro Gattuso’s side in the 83rd minute as AC Milan suffered their first Europa League setback after the opening two wins in Group F.WhatsApplast_img read more