WATSON HIRE ‘AWASH’ WITH 50% BARGAINS THIS WEEKEND

first_imgAdvertising featureIf you have been putting off cleaning the gutters, power-hosing the street, cutting that overgrown hedge or putting up a fence, then this weekend is your chance.Because not only can you do it with ease, you can also do it for 50% less than it would normally cost. For one weekend only Watson Hire in Letterkenny and Donegal Town, in conjunction with Donegaldaily.com, is giving all our readers a half price bargain.No you haven’t heard the number wrong.All hedge-cutters, strimmers, ladders, shampooers, powerwashers and dozens of other hire equipment is half price if you mention Donegal’s leading website – Donegaldaily.com!So what are you waiting for? Get that list of jobs written down and get to it.Watson Hire can be contacted on Letetrkenny 074 9167777 or Donegal Town on 07497 42222. WATSON HIRE ‘AWASH’ WITH 50% BARGAINS THIS WEEKEND was last modified: January 19th, 2012 by StephenShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window) Tags:Watson Hirelast_img read more

Third-Party Ownership Rules Residential Solar Market

first_imgResidential solar is enjoying a surge in popularity, but most homeowners aren’t using their own money to install or maintain it. Greentech Media reports that of a total of 1.2 gigawatts of residential solar installed in 2014, 72% of it was owned by someone other than the customer.While the remainder was directly owned by the customers, much of it was financed through loans.Third-party ownership (TPO) comes in the form of leases or power purchase agreements (PPAs) in which customers sign long-term contracts to buy electricity from the panels the provider installs and maintains. The cost of electricity is typically below that of utility power. Both leases and PPAs give customers access to solar with little or no upfront costs.“The U.S. residential market segment has grown 15 of the last 16 quarters, and that’s largely due to financing solutions like leases,” Greentech Media said. “Since TPO took off a few years ago, the offerings have given customers across many demographics and socioeconomic categories the ability to afford a solar installation.”The biggest players in the TPO market, which collectively accounted for 56% of all residential installations in the U.S., were SolarCity (34%), Vivint Solar (12%) and Sunrun (10%), the report said. Report sees more ownership in years aheadLast year was the third consecutive year that the U.S. residential solar market grew by more than 50%, the report says, but third-party ownership appears to have peaked in 2014.Greentech Media foresees a decline in TPO over the next five years as the total of installed solar rises to 5.2 gigawatts by 2020. Other than a slight uptick in third-party ownership in 2017, coinciding with a drop in the total of solar capacity installed that year, the report shows customer ownership rising to 54% by 2020.The report doesn’t explain the trend in any detail, but notes, “More recently, the market has seen a resurgence of direct ownership, with a number of new players introducing a wide range of loan products. The residential solar market is still in its infancy, and the competitive landscape continues to evolve thanks to new market entrants, acquisitions, and constantly changing consumer finance options.”last_img read more

PBA: Almazan, Camson ejected after trading punches

first_imgTyphoon Kammuri accelerates, gains strength en route to PH Almazan retaliated, gracing Camson with an elbow to the face then punches were thrown before players Ronald Tubid, Don Trollano and the referees helped pacify the situation.Both were ejected after getting slapped with a flagrant foul penalty 2.The two met while being escorted by security on their way to their dugouts on opposite ends of the Cuneta Astrosome hallway and got into a heated verbal exchange.Rain or Shine leads, 44-40, at the half as of posting.ADVERTISEMENT #KicksStalker: Levi’s Jordan IV is classic rock and rap combined Almazan and Camson got tangled near basket while fighting for positioning during a rebound play. Camson appeared to hit first with an elbow that triggered the scuffle. MOST READ LATEST STORIES Brace for potentially devastating typhoon approaching PH – NDRRMC Kammuri turning to super typhoon less likely but possible — Pagasa Asian shares slide on weak Japan data; US markets closed BI on alert for illegally deployed OFWs to Iraqcenter_img 8th Top Leaders Forum assessed the progress of public-private efforts in building climate and disaster resilient communities Do not bring these items in SEA Games venues Read Next View comments Trending Articles PLAY LIST 00:50Trending Articles00:50Trending Articles00:50Trending Articles01:29Police teams find crossbows, bows in HK university01:35Panelo suggests discounted SEA Games tickets for students02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City John Lloyd Cruz a dashing guest at Vhong Navarro’s wedding WARNING: This video contains strong language.Heated hallway exchange between Almazan, Camson after getting ejected. #PBA2018 | @MarkGiongcoINQ pic.twitter.com/O3DARcXY6b— INQUIRER Sports (@INQUIRERSports) January 20, 2018FEATURED STORIESSPORTSWATCH: Drones light up sky in final leg of SEA Games torch runSPORTSLillard, Anthony lead Blazers over ThunderSPORTSMalditas save PH from shutoutThe game between Rain or Shine and Kia turned ugly after Elasto Painters center Raymond Almazan and Picanto big man Eric Camson traded blows late in the second quarter.ADVERTISEMENT Don’t miss out on the latest news and information. last_img read more

IPL 2011: Kolkata seek redemption against Hyderabad

first_imgSmarting from their opening round losses, Kolkata Knight Riders (KKR) and Deccan Chargers (DC) will hope to bring their campaign back on track when they cross swords at the Eden Gardens in Kolkata on Monday.For KKR this will be the first match at their home ground without city’s favourite son Sourav Ganguly whose name had been synonymous with the team so far and provided the side the local flavour.Under new captains in Gautam Gambhir and Kumar Sangakkara, both Kolkata Knight Riders and Deccan Chargers had a similar beginning to the fourth season of the Twenty20 extravaganza – suffering contrasting defeats to Chennai Super Kings and Rajasthan Royals respectively.If Knight Riders gifted the match from a winning position to reigning champions Chennai Super Kings, Deccan Chargers, on the other hand, were outplayed by IPL-1 champions Rajasthan Royals. KKR looked determined to come out of the rut this season, rejigging their line-up for a complete overhaul.Roping in Gautam Gambhir and Yusuf Pathan for the two top signings this season beside successfully bidding for South African Jacques Kallis, Aussie strike bowler Brett Lee, Knights have all the ingredients of a champion side. With talented youngsters in Manoj Tiwary, Manvinder Bisla, Sarabjit Ladda – who showed sparkling signs in their performances against Chennai – Gambhir just needs to get his act together.Deccan Chargers, who lost to the Knights on both the occasions in last season, too are licking their wounds after their morale-shattering loss to Rajasthan Royals and are low in confidence.advertisementThe new look Chargers led by former Kings XI skipper Sangakkara did not click in any of their departments against the Shane Warne’s boys.Sangakkara will have a tough task to fill into the shoes of Adam Gilchrist who provided a top and fourth place finish in IPL-2 and 3.On paper, Deccan’s bowling line-up can be considered as one of the best among the 10 teams with the likes of South African top gun Dale Steyn and Indian spinners Pragyan Ojha and Amit Mishra.It remains to be seen if they can pose any threat to an equally low-on-confidence Knight Riders on Monday.last_img read more

NBA players, coaches appreciate chance to play on MLK Day

first_imgPrivate companies step in to help SEA Games hosting Lacson backs proposal to elect president and vice president in tandem Warriors coach Steve Kerr understands the NBA’s important role on MLK Day.“It’s a great day for the NBA. I think this league is filled with players who are very socially and politically active who want to speak their mind on injustice in general,” Kerr said. “And the fact that our sport really dominates Martin Luther King Day I think is very fitting. It gives the fans a chance to watch great basketball, but it gives everybody some perspective as well, how far we’ve come as a society and how far we have to go. … It’s a great day for the NBA and a great day for our player s in particular.”Around the league beginning last Thursday, players started wearing special warmup shirts by Nike that were designed in collaboration with the MLK Foundation and Martin Luther King III.On the T-shirt, it reads from his historical speech of Aug. 28, 1963: “I have a dream that one day this nation will rise up and live out the true meaning of its creed: ‘We hold these truths to be self-evident, that all men are created equal.’”In Memphis, this will mark the Grizzlies’ 17th annual Martin Luther King Jr. Day Celebration Game when they host New Orleans. Players from both teams toured the National Civil Rights Museum together Sunday.ADVERTISEMENT Oil plant explodes in Pampanga town Oil plant explodes in Pampanga town PH underwater hockey team aims to make waves in SEA Games PLAY LIST 02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games02:11Trump awards medals to Jon Voight, Alison Krauss ‘We are too hospitable,’ says Sotto amid SEA Games woes MOST READ Grace Poe files bill to protect govt teachers from malicious accusations Lakers’ Lonzo Ball to miss 4 to 6 weeks with sprained left ankle Part of the Monday festivities will feature the presentation of the 14th annual National Civil Rights Museum Sports Legacy Award. The honor goes to athletes who, in King’s spirit, have made noteworthy contributions to civil and human rights.Pelicans coach Alvin Gentry said it’s “just a special day.”“Anyone that knows anything about civil rights, or just the rights in general of people, I don’t know how you can’t honor him in every way possible for what he tried to do for individuals, not just the black population, the rights of all people. That’s what makes him special,” said Gentry, who is happy to see a full slate of games as the league honors King. “It does mean a lot to us. If you look at the NBA, they’ve been progressive in that kind of way for a long, long time.“When you look at just civil rights in general and when you look at being inclusive, all of that stuff is something that the NBA has been way ahead of all the other sports.”The rest of the MLK Day lineup includes: Magic at Hawks, Heat at Celtics, Kings at Nets, Bulls at Cavaliers, Mavericks at Bucks, Pistons at Wizards, Rockets at 76ers, Trail Blazers at Jazz.NEW GIGGary Payton and Jason Terry were two of basketball’s biggest talkers as players.Now they have a new platform to keep the comments coming.The former guards will be analysts on “The Bounce,” a built-for-mobile studio show that debuts Monday during the NBA’s MLK Day schedule.The show will air five nights per week — Sunday, Monday, Wednesday, Friday and Saturday — on Yahoo Sports and the Yahoo Sports App from 8 p.m. to 11 p.m. ET through the end of the regular season.center_img SEA Games hosting troubles anger Duterte View comments US judge bars Trump’s health insurance rule for immigrants Featuring scores, highlights and analysis, the show will originate from Turner Sports studios in Atlanta, featuring Turner commentators Rosalyn Gold-Onwude, Allie LaForce and Stephanie Ready as hosts. Women’s star Swin Cash joins Payton and Terry as rotating analysts.CEREMONY RESCHEDULEDWhen the Lakers and Warriors play on Feb. 2 in Oakland, there will be a long-awaited ceremony.Former Warriors center JaVale McGee had been set to receive his championship ring from the Warriors on Christmas night at Oracle Arena, but he was too sick to travel at the time.Kerr has been eager to honor McGee’s role during Golden State’s championships the past two seasons. Don’t miss out on the latest news and information. There will be another full slate of NBA games with 22 of the league’s 30 teams playing on Monday. Knicks coach David Fizdale appreciates how the NBA gives so many teams the chance to play on MLK Day — unlike the more limited schedule on Christmas.“The NBA is just ahead of everything. Adam Silver and those guys just really have a progressive attitude about being inclusive, they understand our history, representing human and civil rights,” Fizdale said. “It’s something that we can be really proud of as a league. MLK Day is another one of those examples of how we try to pay homage and we’re aware of what set the tone and what’s given us the opportunity to be able to do what we do.”FEATURED STORIESSPORTSPrivate companies step in to help SEA Games hostingSPORTSUrgent reply from Philippine ‍football chiefSPORTSWin or don’t eat: the Philippines’ poverty-driven, world-beating pool starsFizdale’s Knicks will host the Oklahoma City Thunder on Monday to tip off the schedule with the Lakers-Warriors capping off the daylong festivities.When Golden State visits Los Angeles to conclude the NBA’s Martin Luther King Jr. Day slate Monday night, Stephen Curry, Durant and the Warriors will try to avenge an embarrassing 127-101 home loss on Christmas night — when the Lakers hung tough even after LeBron James went down with a left groin strain. LATEST STORIES (FILES) In this file photo taken on December 30, 2018 PHOENIX, ARIZONA – DECEMBER 31: Kevin Durant #35 of the Golden State Warriors during NBA game against the Phoenix Suns at Talking Stick Resort Arena on December 31, 2018 in Phoenix, Arizona. – Golden State Warriors star Kevin Durant insisted on January 8, 2019, he’s just focused on playing and not on a potential free agent departure at the end of this NBA season. “I just focus on playing ball every single day,” Durant said as the Warriors prepared to host the New York Knicks — one of the teams that keeps popping up in rumors as a potential Durant destination. (Photo by Christian Petersen / GETTY IMAGES NORTH AMERICA / AFP)OAKLAND, Calif. — Kevin Durant cherishes the opportunity to honor Dr. Martin Luther King Jr. by playing basketball on the holiday that celebrates the civil rights leader.“What MLK meant to the nation and just his message around the world. Still to this day his message has touched so many people,” Durant said. “It’s a good opportunity to play on that day. For us it just means a lot. We carry so much. Each one of us has different journeys throughout life and for us to meet at this point to come out and play a game so special on such a special day, hopefully it brings more people together.”ADVERTISEMENT Sports Related Videospowered by AdSparcRead Nextlast_img read more

Thai league acquires 9 PH booters

first_imgPrivate companies step in to help SEA Games hosting SEA Games hosting troubles anger Duterte ‘We are too hospitable,’ says Sotto amid SEA Games woes Unbeaten Mighty-PH gains QF Don’t miss out on the latest news and information. Sports Related Videospowered by AdSparcRead Next Grace Poe files bill to protect govt teachers from malicious accusations ‘We are too hospitable,’ says Sotto amid SEA Games woes Oil plant explodes in Pampanga town US judge bars Trump’s health insurance rule for immigrants Reigning Thai League champion Buriram United has three Filipino internationals—defender Stephan Palla, Javier Patiño and Luke Woodland.The three were part of the Azkals’ squad that competed in the AFC Asian Cup in the United Arab Emirates last month.FEATURED STORIESSPORTSPrivate companies step in to help SEA Games hostingSPORTSUrgent reply from Philippine ‍football chiefSPORTSPalace wants Cayetano’s PHISGOC Foundation probed over corruption chargesAnother Asian Cup veteran, goalkeeper Michael Falkesgaard, starts his second season with Bangkok United, which he helped to an AFC Champions League last year.The others are former Ceres-Negros star Manny Ott and Amin Nazari (Ratchaburi Mitr Pohl), Iain Ramsay (Sukhothai), Marco Casambre (Chainat Horbill) and Mark Hartmann (Suphanburi). A record number of Filipino players are seeing action in the Thai League 1 this season, including several national team members signing with clubs vying in what is widely considered as Southeast Asia’s top football league.With the Thai league expanding its quota for Southeast Asian players from one to three for each squad, the Philippines will have nine players in the competition that starts on the third week of February.ADVERTISEMENT PDEA chief backs Robredo in revealing ‘discoveries’ on drug war PH underwater hockey team aims to make waves in SEA Games PLAY LIST 02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games02:11Trump awards medals to Jon Voight, Alison Krauss MOST READ LATEST STORIES View commentslast_img read more

a month agoBayern Munich midfielder Coutinho hints Barcelona return unlikely

first_imgBayern Munich midfielder Coutinho hints Barcelona return unlikelyby Carlos Volcanoa month agoSend to a friendShare the loveBayern Munich midfielder Philippe Coutinho has hinted he’s ready to cut ties with Barcelona.Currently on-loan at Bayern, Coutinho says staying long-term in Munich is an option.He stated: “Stay longer in Bayern? Nobody can predict what will happen next year. It depends on many factors. “All I can say is that this year, I will work hard to achieve all our goals. Personally, I want to play a good season. “And then we’ll see where that leads.” TagsTransfersAbout the authorCarlos VolcanoShare the loveHave your saylast_img read more

Gov’t Signs US$15-Million Loan for Energy Efficiency Programme

first_img Minister of Finance and the Public Service, Hon. Audley Shaw, explained that the sum is the second portion of a joint loan of US$30 million for the roll-out of the EMEP. Story Highlights The Government of Jamaica has signed a US$15-million loan agreement with the Japan International Cooperation Agency (JICA) for the implementation of the Energy Management and Efficiency Programme (EMEP). “The aim is to bolster the Government’s efforts in the areas of energy efficiency and conservation through the design and implementation of measures targeting key Government facilities, as well as fuel conservation in road transportation to reduce the demand for fuel imports,” Minister Shaw said. The Government of Jamaica has signed a US$15-million loan agreement with the Japan International Cooperation Agency (JICA) for the implementation of the Energy Management and Efficiency Programme (EMEP).Minister of Finance and the Public Service, Hon. Audley Shaw, explained that the sum is the second portion of a joint loan of US$30 million for the roll-out of the EMEP.He noted that the Government signed an agreement with the Inter-American Development Bank (IDB) for the first US$15 million on November 10.He informed that the European Union (EU) is providing US$10 million in grant funding towards the programme, which will be executed over eight years.“The aim is to bolster the Government’s efforts in the areas of energy efficiency and conservation through the design and implementation of measures targeting key Government facilities, as well as fuel conservation in road transportation to reduce the demand for fuel imports,” Minister Shaw said.He was speaking at the signing ceremony held on Thursday (November 23) at the Ministry’s National Heroes Circle offices in Kingston.Senior Vice President, JICA, Shigeru Maeda, in his remarks, said he is pleased with the partnership.“I am very happy to sign the loan agreement… . I believe that this is a good project for energy conservation, which is important for Jamaica. This programme is in accordance with Vision 2030, which is the national development plan of Jamaica and contributes to achieve the outcome in energy security and efficiency. We expect a great synergy effect with this programme,” Mr. Maeda said.EMEP, which is being executed by the Petroleum Corporation of Jamaica (PCJ) consists of three components.Component one involves retrofitting the Health, Education and Public Agency (HEPA) government facilities. Energy efficiency and conservation measures will be undertaken in 73 HEPAs, including comprehensive retrofitting and installing light-emitting diode (LED) bulbs.Under component two, an Urban Traffic Management System (UTMS) will be implemented in Kingston. This involves installation of a central control platform for traffic monitoring, closed-circuit television cameras, and the training of National Works Agency (NWA) staff.Component three will focus on providing the Ministry of Science, Energy and Technology (MSET) with additional expertise.Training will be undertaken to support the implementation of an Integrated Resource Plan (IRP) to guide the development of a modern energy sector in Jamaica; technical experts will be contracted in energy efficiency and demand side management; and technical studies undertaken to support the IRP.last_img read more

Virginia Tech researcher receives 17 million to study herpes simplex virus

first_imgReviewed by James Ives, M.Psych. (Editor)Oct 11 2018The National Institute of Neurological Disorders and Stroke (NINDS) of the National Institutes of Health has awarded Andrea Bertke, an assistant professor of infectious diseases in the Department of Population Health Sciences in the Virginia-Maryland College of Veterinary Medicine at Virginia Tech, $1.7 million to study the neuron-specific regulation of herpes simplex viruses 1 and 2 (HSV1 and HSV2).HSV1 and HSV2 are highly contagious and incurable. The viruses establish latency in sensory and autonomic neurons (nerve cells), from which they can reactivate to cause recurrent disease, affecting more than 250 million people in the U.S. alone, according to Bertke.HSV1 is typically associated with cold sores, also known as oral herpes, and HSV2 with genital herpes, although either one can be transmitted to either site. In addition to skin lesions and pain, they can cause blinding ocular infection, meningitis, and encephalitis. In fact, HSV1 is one of the leading causes of infectious corneal blindness in the world and, according to World Health Organization estimates, over half a billion people between the ages of 15-49 years have genital infection caused by either HSV1 or HSV2.Some types of neurons support HSV replication upon entry, while other types naturally inhibit replication, resulting in latency. HSV only reactivates from a portion of the latently infected neurons, causing recurrent disease and viral shedding. In addition, the subtypes of neurons that support these different outcomes of infection are different for HSV1 and HSV2.”The goal of this project is to figure out how some neurons naturally shut down virus replication initially and what intrinsic inhibitory mechanisms in those neurons shut it down,” Bertke said. “If we can find those mechanisms, we can exploit them to prevent replication in all neurons.”Previous studies of HSV regulatory mechanisms have relied on whole tissues, cell lines, or embryonic neuronal cultures, which do not permit analysis of neuron type-specific mechanisms.”How these mechanisms differ between HSV1 and HSV2, leading to different patterns and frequencies of recurrent disease, is grossly understudied,” Bertke said. “Understanding how different types of mature neurons regulate viral infections represents a significant gap in knowledge, one that is of critical importance, since neurons are long-lived terminally differentiated cells not easily replaced in adults.”Related StoriesScientists discover weakness in common cold virusVirus employs powerful strategy to inhibit natural killer cell functionVirus killing protein could be the real antiviral hero finds studyBertke’s research team previously determined that in adult sensory neurons, continuous presence of certain neurotrophic factors maintains HSV in a latent state, and deprivation of these factors selectively induces viral reactivation. With the new five-year grant, the team will build on their work to identify what they call the “latency lock” – the development of a molecule or antiviral that can latch onto the virus and permanently lock it in a latent state incapable of reactivation, in any type of neuron.”In these studies, we will identify specific neuron signaling pathways that allow the virus to reactivate and determine if there are inhibitors that will prevent the reactivation process,” said Bertke. “If we can put those mechanisms together, we may be able to permanently shut down the virus. Then, we’ll never have recurrent disease or viral shedding, and we’ll never have it spreading to other hosts.”Other Virginia Tech scholars on the project team include Telvin Harrell, Ph.D. student in the veterinary college’s biomedical and veterinary sciences program and former Multicultural Academic Opportunities Program mentee in the Bertke lab; Poorna Goswami, Ph.D. student in translational biology, medicine, and health; Lindsey Henry, master’s student in public health; and two undergraduate students, Amber Abbott, junior in microbiology, and Dominique Ngo, senior in biology and Spanish. Jack Thompson, senior in biochemistry, helped to develop preliminary data for the project.Other collaborators on the project include Seth Frietze, assistant professor at the University of Vermont College of Nursing and Health Sciences and co-investigator on the grant, and Anna Cliffe, assistant professor at the University of Virginia School of Medicine.This is Bertke’s second grant from NINDS this year; the first was a two-year grant awarded in April. She and co-investigator David Davido, associate professor at the University of Kansas, are working to identify the role of an HSV1 protein, ICP0, in latency and reactivation in neurons.Source: https://vtnews.vt.edu/articles/2018/10/vetmed-bertke-grant.htmllast_img read more

Photoacoustic imaging accurately measures the temperature of deep tissues

first_imgReviewed by James Ives, M.Psych. (Editor)Feb 14 2019Non-invasive imaging technique could greatly enhance cancer therapiesMeasuring a fever is usually pretty simple: place a thermometer under a patient’s tongue and get an accurate temperature reading within 30 seconds. But that simplicity does not translate when it comes to measuring the temperatures of specific tissues deep inside the body.Biomedical engineers at Duke University have demonstrated how photoacoustic imaging can take the temperature of deep tissue more quickly and accurately than current techniques. This discovery is expected to play an important role in advancing thermal-based therapies to treat cancer. The research appears February 12 in the journal Optica.Tracking the temperature of internal tissues is essential for many biomedical studies and thermal therapies of cancers, often affecting a treatment’s efficiency or side effects.”If we use MRI or ultrasound, we’re looking at relative temperature and operating under the assumption that the patient has a baseline temperature of 98 degrees Fahrenheit, which isn’t always the case,” said Junjie Yao, assistant professor of biomedical engineering at Duke. “We found a way to measure absolute temperature by using photoacoustic imaging to probe the thermal memory of the tissue.”As the name implies, photoacoustic imaging allows researchers to combine the properties of light and sound. This technique allows researchers to convert light beamed through tissue into ultrasound waves that can then be analyzed to create high-resolution images.”It’s basically compressing one second’s worth of summer-noon sunlight over a fingernail area in a single nanosecond,” said Yao, who has been working with the technology for nearly a decade. “When the laser hits a cell, the energy causes it to heat up a tiny bit and expand instantaneously, creating an ultrasonic wave. It’s analogous to striking a bell to cause it to ring.”According to Yao, researchers have wanted to use photoacoustic imaging to measure temperature for a long time, but they’ve consistently experienced technical roadblocks.”The conversion efficiency between light and sound is temperature-dependent, so we know it’s possible to measure temperature by listening to soundwaves generated by light,” Yao said. “However, we haven’t previously been able to measure absolute temperature because the process itself needs to know how many photons are reaching the tissue, which is technically challenging.”Related StoriesComplement system shown to remove dead cells in retinitis pigmentosa, contradicting previous researchLight at last: why do more women develop Alzheimer’s disease?’Eye-in-a-dish’ model helps scientists to uncover ‘surprising’ AMD gene variantTo get around this missing information, Yao is working with Pei Zhong, a professor in the department of mechanical engineering and materials science who has generated deep tissue heating using high intensity focused ultrasound (HIFU). Their team devised a new approach named thermal-energy-memory-based photoacoustic thermometry, or TEMPT, which uses photoacoustic imaging to measure the tissue’s “thermal memory.”With TEMPT, researchers take a baseline temperature reading before bombarding the tissue with a burst of nanosecond-long laser pulses. The pulses temporarily increase the tissue’s temperature, which is then measured using another photoacoustic pulse.The research team was able to use these measurements and a mathematical model to estimate the absolute temperature without knowing how many photons were delivered.The ability to more precisely measure the temperature of tissues deep in the body has important implications for treating cancer with thermal ablation, which involves heating up tumor cells using HIFU or radio waves until they die. Although thermotherapy is a newcomer in the battle of fighting cancers, researchers are very enthusiastic about this treatment because it doesn’t cause the serious side-effects associated with radiotherapy and chemotherapy.”One of the challenges with thermotherapy is that we need to keep the temperature in the most efficient range,” Yao said. “If the temperature is too high, we can damage the surrounding tissues, and if it’s too low, we’re not causing enough damage to the tumor. The TEMPT technology could be incorporated into the treatments to hone in on the perfect temperature.”Yao said researchers are eager to explore the most precise temperature range for efficiently killing tumor cells. Beyond the therapeutic potential, Yao and his collaborators are also examining how their work can be applied to other fundamental research questions.”We’re already forming new collaborations, both with physicians and engineers, to continue to advance this new technology in the lab and beyond,” Yao said. “This is very exciting because it can potentially be translated to clinical impacts and benefit cancer patients.” Source:http://www.duke.edu/last_img read more